DNA demethylation by DNA repair - PubMed (original) (raw)

Review

DNA demethylation by DNA repair

Mary Gehring et al. Trends Genet. 2009 Feb.

Abstract

Active DNA demethylation underlies key facets of reproduction in flowering plants and mammals and serves a general genome housekeeping function in plants. A family of 5-methylcytosine DNA glycosylases catalyzes plant demethylation via the well-known DNA base-excision-repair process. Although the existence of active demethylation has been known for a longer time in mammals, the means of achieving it remain murky and mammals lack counterparts to the plant demethylases. Several intriguing experiments have indicated, but not conclusively proven, that DNA repair is also a plausible mechanism for animal demethylation. Here, we examine what is known from flowering plants about the pathways and function of enzymatic demethylation and discuss possible mechanisms whereby DNA repair might also underlie global demethylation in mammals.

PubMed Disclaimer

Cited by

MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.
Papin C, Ibrahim A, Sabir JSM, Le Gras S, Stoll I, Albiheyri RS, Zari AT, Bahieldin A, Bellacosa A, Bronner C, Hamiche A. Papin C, et al. J Exp Clin Cancer Res. 2023 Nov 14;42(1):301. doi: 10.1186/s13046-023-02882-z. J Exp Clin Cancer Res. 2023. PMID: 37957685 Free PMC article.
Predicting meningioma grades and pathologic marker expression via deep learning.
Chen J, Xue Y, Ren L, Lv K, Du P, Cheng H, Sun S, Hua L, Xie Q, Wu R, Gong Y. Chen J, et al. Eur Radiol. 2024 May;34(5):2997-3008. doi: 10.1007/s00330-023-10258-2. Epub 2023 Oct 19. Eur Radiol. 2024. PMID: 37853176
Transcriptome analysis provides insight into the regulatory mechanisms underlying pollen germination recovery at normal high ambient temperature in wild banana (Musa itinerans).
Zhang C, Zhang C, Xu X, Liao M, Tong N, Zhang Z, Chen Y, Xu Han X, Lin Y, Lai Z. Zhang C, et al. Front Plant Sci. 2023 Sep 26;14:1255418. doi: 10.3389/fpls.2023.1255418. eCollection 2023. Front Plant Sci. 2023. PMID: 37822335 Free PMC article.
Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort.
Janoš T, Ottenbros I, Bláhová L, Šenk P, Šulc L, Pálešová N, Sheardová J, Vlaanderen J, Čupr P. Janoš T, et al. Environ Res. 2023 Apr 1;222:115368. doi: 10.1016/j.envres.2023.115368. Epub 2023 Jan 28. Environ Res. 2023. PMID: 36716809 Free PMC article.
Epigenetics and its role in effecting agronomical traits.
Gupta C, Salgotra RK. Gupta C, et al. Front Plant Sci. 2022 Aug 15;13:925688. doi: 10.3389/fpls.2022.925688. eCollection 2022. Front Plant Sci. 2022. PMID: 36046583 Free PMC article. Review.

DNA demethylation by DNA repair - PubMed (original) (raw)