Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies - PubMed (original) (raw)
Review
Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
D Sugiyama et al. Ann Rheum Dis. 2010 Jan.
Abstract
Objectives: To assess whether smoking is a risk factor for developing rheumatoid arthritis (RA).
Design: Meta-analysis.
Data sources: were observational studies that examined the association between smoking history and the risk of developing RA identified through Medline and EMBASE (from 1966 to December 2006), relevant books and a reference search. Two authors independently extracted the following: authors' names, publication year, sample size, participant characteristics, odds ratios (OR) or relative risks, adjustment factors, study design and area where the study was conducted. Data syntheses were based upon random effects model. Summarised syntheses effects were expressed by OR.
Results: Sixteen studies were selected from among 433 articles. For men, summary OR for ever, current and past smokers were 1.89 (95% CI 1.56 to 2.28), 1.87 (1.49 to 2.34) and 1.76 (1.33 to 2.31), respectively. For rheumatoid factor-positive (RF+) RA, summary OR for ever, current and past smokers were 3.02 (2.35 to 3.88), 3.91 (2.78 to 5.50) and 2.46 (1.74 to 3.47), respectively. Summary OR for 20 or more pack-years of smoking was 2.31 (1.55 to 3.41). For women, summary OR for ever, current and past smokers were 1.27 (1.12 to 1.44), 1.31 (1.12 to 1.54) and 1.22 (1.06 to 1.40), respectively. For RF+ RA, summary OR for ever, current and past smokers were 1.34 (0.99 to 1.80), 1.29 (0.94 to 1.77) and 1.21 (0.83 to 1.77). Summary OR for 20 or more pack-years of smoking was 1.75 (1.52 to 2.02).
Conclusion: Smoking is a risk factor for RA, especially RF+ RA men and heavy smokers.
Similar articles
- Cigarette smoking and risk of rheumatoid arthritis: a dose-response meta-analysis.
Di Giuseppe D, Discacciati A, Orsini N, Wolk A. Di Giuseppe D, et al. Arthritis Res Ther. 2014 Mar 5;16(2):R61. doi: 10.1186/ar4498. Arthritis Res Ther. 2014. PMID: 24594022 Free PMC article. - Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women.
Costenbader KH, Feskanich D, Mandl LA, Karlson EW. Costenbader KH, et al. Am J Med. 2006 Jun;119(6):503.e1-9. doi: 10.1016/j.amjmed.2005.09.053. Am J Med. 2006. PMID: 16750964 - Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases.
Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L; EIRA study group. Stolt P, et al. Ann Rheum Dis. 2003 Sep;62(9):835-41. doi: 10.1136/ard.62.9.835. Ann Rheum Dis. 2003. PMID: 12922955 Free PMC article. Review. - A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis.
Padyukov L, Silva C, Stolt P, Alfredsson L, Klareskog L. Padyukov L, et al. Arthritis Rheum. 2004 Oct;50(10):3085-92. doi: 10.1002/art.20553. Arthritis Rheum. 2004. PMID: 15476204 - Rheumatoid factor and response to TNF antagonists in rheumatoid arthritis: systematic review and meta-analysis of observational studies.
Salgado E, Maneiro JR, Carmona L, Gómez-Reino J. Salgado E, et al. Joint Bone Spine. 2014 Jan;81(1):41-50. doi: 10.1016/j.jbspin.2013.04.004. Epub 2013 Jun 2. Joint Bone Spine. 2014. PMID: 23731644 Review.
Cited by
- Sex-specific environmental influences on the development of autoimmune diseases.
Tiniakou E, Costenbader KH, Kriegel MA. Tiniakou E, et al. Clin Immunol. 2013 Nov;149(2):182-91. doi: 10.1016/j.clim.2013.02.011. Epub 2013 Feb 28. Clin Immunol. 2013. PMID: 23507400 Free PMC article. Review. - Immune-Mediated Inflammatory Diseases and Cancer - a dangerous liaison.
Maier JA, Castiglioni S, Petrelli A, Cannatelli R, Ferretti F, Pellegrino G, Sarzi Puttini P, Fiorina P, Ardizzone S. Maier JA, et al. Front Immunol. 2024 Sep 18;15:1436581. doi: 10.3389/fimmu.2024.1436581. eCollection 2024. Front Immunol. 2024. PMID: 39359726 Free PMC article. Review. - Association Between the Extent of Periodontal Inflammation and the Severity of Rheumatoid Arthritis in Japanese Patients With Rheumatoid Arthritis.
Hashimoto H, Hashimoto S, Shimazaki Y. Hashimoto H, et al. Int Dent J. 2021 Oct;71(5):429-437. doi: 10.1016/j.identj.2020.12.015. Epub 2021 Mar 17. Int Dent J. 2021. PMID: 33741141 Free PMC article. - Impact of a Rheumatology Clinic Protocol on Tobacco Cessation Quit Line Referrals.
Bartels CM, Johnson L, Ramly E, Panyard DJ, Gilmore-Bykovskyi A, Johnson HM, McBride P, Li Z, Sampene E, Lauver DR, Lewicki K, Piper ME. Bartels CM, et al. Arthritis Care Res (Hoboken). 2022 Sep;74(9):1421-1429. doi: 10.1002/acr.24589. Epub 2022 May 27. Arthritis Care Res (Hoboken). 2022. PMID: 33825349 Free PMC article. - The challenging interplay between rheumatoid arthritis, ageing and comorbidities.
van Onna M, Boonen A. van Onna M, et al. BMC Musculoskelet Disord. 2016 Apr 26;17:184. doi: 10.1186/s12891-016-1038-3. BMC Musculoskelet Disord. 2016. PMID: 27118031 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous