A role for RNAi in the selective correction of DNA methylation defects - PubMed (original) (raw)
. 2009 Mar 20;323(5921):1600-4.
doi: 10.1126/science.1165313. Epub 2009 Jan 29.
Fabiana Heredia, Alexis Sarazin, François Roudier, Martine Boccara, Constance Ciaudo, Corinne Cruaud, Julie Poulain, Maria Berdasco, Mario F Fraga, Olivier Voinnet, Patrick Wincker, Manel Esteller, Vincent Colot
Affiliations
- PMID: 19179494
- DOI: 10.1126/science.1165313
A role for RNAi in the selective correction of DNA methylation defects
Felipe Karam Teixeira et al. Science. 2009.
Abstract
DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, which suggests that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis (as in cancer) or meiosis, leading to epiallelic variation. We demonstrated the existence of an efficient mechanism that protects against transgenerational loss of DNA methylation in Arabidopsis. Remethylation is specific to the subset of heavily methylated repeats that are targeted by the RNA interference (RNAi) machinery. This process does not spread into flanking regions, is usually progressive over several generations, and faithfully restores wild-type methylation over target sequences in an RNAi-dependent manner. Our findings suggest an important role for RNAi in protecting genomes against long-term epigenetic defects.
Comment in
- Molecular biology. Dynamic DNA methylation.
Law JA, Jacobsen SE. Law JA, et al. Science. 2009 Mar 20;323(5921):1568-9. doi: 10.1126/science.1172782. Science. 2009. PMID: 19299607 No abstract available.
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