Changes in cortical dopamine D1 receptor binding associated with cognitive training - PubMed (original) (raw)
. 2009 Feb 6;323(5915):800-2.
doi: 10.1126/science.1166102.
Affiliations
- PMID: 19197069
- DOI: 10.1126/science.1166102
Changes in cortical dopamine D1 receptor binding associated with cognitive training
Fiona McNab et al. Science. 2009.
Abstract
Working memory is a key function for human cognition, dependent on adequate dopamine neurotransmission. Here we show that the training of working memory, which improves working memory capacity, is associated with changes in the density of cortical dopamine D1 receptors. Fourteen hours of training over 5 weeks was associated with changes in both prefrontal and parietal D1 binding potential. This plasticity of the dopamine D1 receptor system demonstrates a reciprocal interplay between mental activity and brain biochemistry in vivo.
Similar articles
- A functional magnetic resonance imaging study of the effects of pergolide, a dopamine receptor agonist, on component processes of working memory.
Gibbs SE, D'Esposito M. Gibbs SE, et al. Neuroscience. 2006 Apr 28;139(1):359-71. doi: 10.1016/j.neuroscience.2005.11.055. Epub 2006 Feb 3. Neuroscience. 2006. PMID: 16458442 - Under the curve: critical issues for elucidating D1 receptor function in working memory.
Williams GV, Castner SA. Williams GV, et al. Neuroscience. 2006 Apr 28;139(1):263-76. doi: 10.1016/j.neuroscience.2005.09.028. Epub 2005 Nov 28. Neuroscience. 2006. PMID: 16310964 Review. - Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET.
Okubo Y, Suhara T, Suzuki K, Kobayashi K, Inoue O, Terasaki O, Someya Y, Sassa T, Sudo Y, Matsushima E, Iyo M, Tateno Y, Toru M. Okubo Y, et al. Nature. 1997 Feb 13;385(6617):634-6. doi: 10.1038/385634a0. Nature. 1997. PMID: 9024661 - D1 dopamine receptors in the mouse prefrontal cortex: Immunocytochemical and cognitive neuropharmacological analyses.
Lidow MS, Koh PO, Arnsten AF. Lidow MS, et al. Synapse. 2003 Feb;47(2):101-8. doi: 10.1002/syn.10143. Synapse. 2003. PMID: 12454947 - Tuning the engine of cognition: a focus on NMDA/D1 receptor interactions in prefrontal cortex.
Castner SA, Williams GV. Castner SA, et al. Brain Cogn. 2007 Mar;63(2):94-122. doi: 10.1016/j.bandc.2006.11.002. Epub 2007 Jan 3. Brain Cogn. 2007. PMID: 17204357 Review.
Cited by
- Plasticity in D1-like receptor expression is associated with different components of cognitive processes.
Herold C, Joshi I, Chehadi O, Hollmann M, Güntürkün O. Herold C, et al. PLoS One. 2012;7(5):e36484. doi: 10.1371/journal.pone.0036484. Epub 2012 May 4. PLoS One. 2012. PMID: 22574169 Free PMC article. - A pilot study on the benefit of cognitive rehabilitation in Parkinson's disease.
Adamski N, Adler M, Opwis K, Penner IK. Adamski N, et al. Ther Adv Neurol Disord. 2016 May;9(3):153-64. doi: 10.1177/1756285616628765. Epub 2016 Feb 16. Ther Adv Neurol Disord. 2016. PMID: 27134671 Free PMC article. - COMT and 5-HT1A-receptor genotypes potentially affect executive functions improvement after cognitive remediation in schizophrenia.
Bosia M, Bechi M, Pirovano A, Buonocore M, Lorenzi C, Cocchi F, Bramanti P, Smeraldi E, Cavallaro R. Bosia M, et al. Health Psychol Behav Med. 2014 Jan 1;2(1):509-516. doi: 10.1080/21642850.2014.905206. Epub 2014 Apr 28. Health Psychol Behav Med. 2014. PMID: 25750798 Free PMC article. - Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.
Converse AK, Moore CF, Holden JE, Ahlers EO, Moirano JM, Larson JA, Resch LM, DeJesus OT, Barnhart TE, Nickles RJ, Murali D, Christian BT, Schneider ML. Converse AK, et al. Alcohol Clin Exp Res. 2014 Dec;38(12):2934-43. doi: 10.1111/acer.12575. Alcohol Clin Exp Res. 2014. PMID: 25581649 Free PMC article. - Improving outcome of treatment-resistant schizophrenia: effects of cognitive remediation therapy.
Martini F, Spangaro M, Bechi M, Agostoni G, Buonocore M, Sapienza J, Nocera D, Ave C, Cocchi F, Cavallaro R, Bosia M. Martini F, et al. Eur Arch Psychiatry Clin Neurosci. 2024 Sep;274(6):1473-1481. doi: 10.1007/s00406-023-01731-6. Epub 2023 Dec 19. Eur Arch Psychiatry Clin Neurosci. 2024. PMID: 38114732
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources