Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease - PubMed (original) (raw)

doi: 10.1038/ng.314. Epub 2009 Feb 8.

Inke R König, Jeanette Erdmann, Alexandru Munteanu, Peter S Braund, Alistair S Hall, Anika Grosshennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J Wright, Michael Preuss, Anthony J Balmforth, Stephen G Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald Luc, Jean-Bernard Ruidavets, Caroline Morrison, Pim van der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H-Erich Wichmann, Christian Hengstenberg, Willem Ouwehand; Wellcome Trust Case Control Consortium; Cardiogenics Consortium; Andreas Ziegler, Laurence Tiret, John R Thompson, Francois Cambien, Heribert Schunkert, Nilesh J Samani

Affiliations

• PMID: 19198611
• DOI: 10.1038/ng.314

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

David-Alexandre Trégouët et al. Nat Genet. 2009 Mar.

Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

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