D-amino acid oxidase: physiological role and applications - PubMed (original) (raw)

Review

. 2008 Dec;73(13):1511-8.

doi: 10.1134/s0006297908130105.

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• PMID: 19216715
• DOI: 10.1134/s0006297908130105

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Review

D-amino acid oxidase: physiological role and applications

S V Khoronenkova et al. Biochemistry (Mosc). 2008 Dec.

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Abstract

D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.

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