Synaptic AMPA receptor plasticity and behavior - PubMed (original) (raw)

Review

Synaptic AMPA receptor plasticity and behavior

Helmut W Kessels et al. Neuron. 2009.

Abstract

The ability to change behavior likely depends on the selective strengthening and weakening of brain synapses. The cellular models of synaptic plasticity, long-term potentiation (LTP) and depression (LTD) of synaptic strength, can be expressed by the synaptic insertion or removal of AMPA receptors (AMPARs), respectively. We here present an overview of studies that have used animal models to show that such AMPAR trafficking underlies several experience-driven phenomena-from neuronal circuit formation to the modification of behavior. We argue that monitoring and manipulating synaptic AMPAR trafficking represents an attractive means to study cognitive function and dysfunction in animal models.

PubMed Disclaimer

Cited by

BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met.
Mizui T, Ishikawa Y, Kumanogoh H, Lume M, Matsumoto T, Hara T, Yamawaki S, Takahashi M, Shiosaka S, Itami C, Uegaki K, Saarma M, Kojima M. Mizui T, et al. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3067-74. doi: 10.1073/pnas.1422336112. Epub 2015 May 26. Proc Natl Acad Sci U S A. 2015. PMID: 26015580 Free PMC article.
Caspases in synaptic plasticity.
Li Z, Sheng M. Li Z, et al. Mol Brain. 2012 May 14;5:15. doi: 10.1186/1756-6606-5-15. Mol Brain. 2012. PMID: 22583788 Free PMC article. Review.
MSK1 regulates homeostatic and experience-dependent synaptic plasticity.
Corrêa SA, Hunter CJ, Palygin O, Wauters SC, Martin KJ, McKenzie C, McKelvey K, Morris RG, Pankratov Y, Arthur JS, Frenguelli BG. Corrêa SA, et al. J Neurosci. 2012 Sep 19;32(38):13039-51. doi: 10.1523/JNEUROSCI.0930-12.2012. J Neurosci. 2012. PMID: 22993422 Free PMC article.
Willardiine and Its Synthetic Analogues: Biological Aspects and Implications in Peptide Chemistry of This Nucleobase Amino Acid.
Palumbo R, Omodei D, Vicidomini C, Roviello GN. Palumbo R, et al. Pharmaceuticals (Basel). 2022 Oct 10;15(10):1243. doi: 10.3390/ph15101243. Pharmaceuticals (Basel). 2022. PMID: 36297355 Free PMC article. Review.
Effects of metabolic state on the regulation of melanocortin circuits.
Lieu L, Chau D, Afrin S, Dong Y, Alhadeff AL, Betley JN, Williams KW. Lieu L, et al. Physiol Behav. 2020 Oct 1;224:113039. doi: 10.1016/j.physbeh.2020.113039. Epub 2020 Jun 28. Physiol Behav. 2020. PMID: 32610101 Free PMC article. Review.

References

1. Adesnik H, Nicoll RA. Conservation of glutamate receptor 2-containing AMPA receptors during long-term potentiation. J. Neurosci. 2007;27:4598–4602. - PMC - PubMed
1. Ahmadian G, Ju W, Liu L, Wyszynski M, Lee SH, Dunah AW, Taghibiglou C, Wang Y, Lu J, Wong TP, et al. Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD. EMBO J. 2004;23:1040–1050. - PMC - PubMed
1. Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis. 2005;20:187–198. - PubMed
1. Andrasfalvy BK, Smith MA, Borchardt T, Sprengel R, Magee JC. Impaired regulation of synaptic strength in hippocampal neurons from GluR1-deficient mice. J. Physiol. 2003;552:35–45. - PMC - PubMed
1. Anisman H, Zaharia MD, Meaney MJ, Merali Z. Do early-life events permanently alter behavioral and hormonal responses to stressors? Int. J. Dev. Neurosci. 1998;16:149–164. - PubMed

Synaptic AMPA receptor plasticity and behavior - PubMed (original) (raw)