Calcium plus vitamin D supplementation and mortality in postmenopausal women: the Women's Health Initiative calcium-vitamin D randomized controlled trial - PubMed (original) (raw)
Randomized Controlled Trial
doi: 10.1093/gerona/glp006. Epub 2009 Feb 16.
Jane Kotchen, Garnet Anderson, Robert Brzyski, Jane A Cauley, Steven R Cummings, Margery Gass, Karen C Johnson, Marcia Ko, Joseph Larson, JoAnn E Manson, Marcia L Stefanick, Jean Wactawski-Wende
Affiliations
- PMID: 19221190
- PMCID: PMC2800808
- DOI: 10.1093/gerona/glp006
Randomized Controlled Trial
Calcium plus vitamin D supplementation and mortality in postmenopausal women: the Women's Health Initiative calcium-vitamin D randomized controlled trial
Andrea Z LaCroix et al. J Gerontol A Biol Sci Med Sci. 2009 May.
Abstract
Background: Calcium and vitamin D (CaD) supplementation trials including the Women's Health Initiative (WHI) trial of CaD have shown nonsignificant reductions in total mortality. This report examines intervention effects on total and cause-specific mortality by age and adherence.
Methods: The WHI CaD trial was a randomized, double-blind, placebo-controlled trial that enrolled 36,282 postmenopausal women aged 51-82 years from 40 U.S. clinical centers. Women were assigned to 1,000 mg of elemental calcium carbonate and 400 IU of vitamin D(3) daily or placebo with average follow-up of 7.0 years.
Results: The hazard ratio (HR) for total mortality was 0.91 (95% confidence interval [CI], 0.83-1.01) with 744 deaths in women randomized to CaD versus 807 deaths in the placebo group. HRs were in the direction of reduced risk but nonsignificant for stroke and cancer mortality, but near unity for coronary heart disease and other causes of death. HRs for total mortality were 0.89 in the 29,942 women younger than 70 years (95% CI, 0.79-1.01) and 0.95 in the 6,340 women aged 70 and older (95% CI, 0.80-1.12; p value for age interaction = .10). No statistically significant interactions were observed for any baseline characteristics. Treatment effects did not vary significantly by season.
Conclusions: In the WHI CaD trial, supplementation did not have a statistically significant effect on mortality rates but the findings support the possibility that these supplements may reduce mortality rates in postmenopausal women. These data can neither support nor refute recommendations for higher dose vitamin D supplementation to reduce cancer or total mortality.
Trial registration: ClinicalTrials.gov NCT00000611.
Figures
Figure 1.
Cumulative mortality Kaplan–Meier curves by age group. Note: CaD = calcium and vitamin D; CI = confidence interval; HR = hazard ratio.
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References
- Jackson RD, LaCroix AZ, Gass M, et al. for the Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354:669–683. - PubMed
- Prince RL, Devine A, Dhaliwal SS, Dick IM. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med. 2006;166:869–875. - PubMed
- Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007;167:1730–1737. - PubMed
- Wactawski-Wende J, Kotchen JM, Anderson GL, et al. For the Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006;354:684–696. - PubMed
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