The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation - PubMed (original) (raw)
. 1991 Sep 26;353(6342):321-5.
doi: 10.1038/353321a0.
Affiliations
- PMID: 1922337
- DOI: 10.1038/353321a0
The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation
D R Madden et al. Nature. 1991.
Abstract
X-ray crystallography reveals electron density in the antigen-binding site of HLA-B27 that is an interpretable image of nonameric peptides in a largely extended conformation. Clear density exists for the main chain and several side chains and is consistent with the sequence of 11 nonameric self-peptides eluted from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the amino and carboxyl termini of the peptide.
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