In very young infants severity of acute bronchiolitis depends on carried viruses - PubMed (original) (raw)
doi: 10.1371/journal.pone.0004596. Epub 2009 Feb 25.
Marc Lubrano, Marie Gueudin, Pascal Le Roux, Antoine Deschildre, Chantal Forget, Laure Couderc, Daniel Siret, Marie-Dominique Donnou, Michael Bubenheim, Astrid Vabret, François Freymuth
Affiliations
- PMID: 19240806
- PMCID: PMC2644758
- DOI: 10.1371/journal.pone.0004596
In very young infants severity of acute bronchiolitis depends on carried viruses
Christophe Marguet et al. PLoS One. 2009.
Abstract
Background: RT amplification reaction has revealed that various single viruses or viral co-infections caused acute bronchiolitis in infants, and RV appeared to have a growing involvement in early respiratory diseases. Because remaining controversial, the objective was to determine prospectively the respective role of RSV, RV, hMPV and co-infections on the severity of acute bronchiolitis in very young infants.
Methods and principal findings: 209 infants (median age: 2.4 months) were enrolled in a prospective study of infants <1 year old, hospitalized for a first episode of bronchiolitis during the winter epidemic season and with no high risk for severe disease. The severity was assessed by recording SaO(2)% at admission, a daily clinical score (scale 0-18), the duration of oxygen supplementation and the length of hospitalization. Viruses were identified in 94.7% by RT amplification reaction: RSV only (45.8%), RV only (7.2%), hMPV only (3.8%), dual RSV/RV (14.3%), and other virus only (2%) or coinfections (9%). RV compared respectively with RSV and dual RSV/RV infection caused a significant less severe disease with a lower clinical score (5[3.2-6] vs. 6[4-8], p = 0.01 and 5.5[5-7], p = 0.04), a shorter time in oxygen supplementation (0[0-1] days vs. 2[0-3] days, p = 0.02 and 2[0-3] days, p = 0.03) and a shorter hospital stay (3[3-4.7] days vs.6 [5-8] days, p = 0.001 and 5[4-6] days, p = 0.04). Conversely, RSV infants had also longer duration of hospitalization in comparison with RSV/RV (p = 0.01) and hMPV (p = 0.04). The multivariate analyses showed that the type of virus carried was independently associated with the duration of hospitalization.
Conclusion: This study underlined the role of RV in early respiratory diseases, as frequently carried by young infants with a first acute bronchiolitis. RSV caused the more severe disease and conversely RV the lesser severity. No additional effect of dual RSV/RV infection was observed on the severity.
Conflict of interest statement
Competing Interests: The authors have declared that no competing interests exist.
Figures
Figure 1. Severity of acute bronchiolitis with regards to the viral etiology.
The following groups were compared: RVS alone (n = 96), RV alone (n = 15), dual RVS/RV infection (n = 30), and hMPV alone (n = 8). The studied criteria of severity were clinical score (A), SaO2% at the admission (B), oxygen supplementation (C) and duration of hospitalization (D).
References
- Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, et al. Bronchiolitis-associated hospitalizations among US children, 1980–1996. JAMA. 1999;282:1440–1446. - PubMed
- Papadopoulos NG, Moustaki M, Tsolia M, Bossios A, Astra E, et al. Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med. 2002;165:1285–1299. - PubMed
- Richard N, Komurian-Pradel F, Javouhey E, Perret M, Rajoharison A, et al. The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis. Pediatr Infect Dis J. 2008;27:213–217. - PubMed
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