Building a vessel wall with notch signaling - PubMed (original) (raw)
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Building a vessel wall with notch signaling
Jenna N Regan et al. Circ Res. 2009.
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Figure 1
Mural cells (pericytes) are closely associated with endothelial cells in the microvasculature. Contact between mural cells and endothelial cells that are expressing the Notch ligand Jagged1 induces expression of both the Notch3 receptor and Jagged1 in mural cells. Upregulation of notch signaling in mural cells is associated with increased expression of SMC differentiation marker genes indicative of a maturation response by the mural cell. The predicted outcome of this interaction is to stabilize the contact between mural cell and endothelial cell, and to promote the formation of more robust microvascular networks in angiogenesis and in vascular network remodeling.
Comment on
- NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1.
Liu H, Kennard S, Lilly B. Liu H, et al. Circ Res. 2009 Feb 27;104(4):466-75. doi: 10.1161/CIRCRESAHA.108.184846. Epub 2009 Jan 15. Circ Res. 2009. PMID: 19150886 Free PMC article.
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