X chromosome inactivation sparked by non-coding RNAs - PubMed (original) (raw)
Review
. 2009 Apr-Jun;6(2):94-9.
doi: 10.4161/rna.6.2.7716. Epub 2009 Apr 20.
Affiliations
- PMID: 19246991
- DOI: 10.4161/rna.6.2.7716
Review
X chromosome inactivation sparked by non-coding RNAs
Martin Leeb et al. RNA Biol. 2009 Apr-Jun.
Abstract
Non-coding RNAs regulate dosage compensation in mammals by controlling transcriptional silencing of one of the two X chromosomes in females. The two major transcripts involved in this process are Xist and its antisense counterpart Tsix. Expression of Xist and Tsix from the X inactivation center is mutually exclusive. Xist expression triggers chromosome wide silencing of the X chromosome from which it is transcribed. Tsix is a repressor of Xist and is specifically expressed from the other X chromosome, maintaining its activity. Here, we review non-coding RNAs that have been implicated in X chromosome inactivation. Focusing on the best studied transcripts Xist and Tsix we portray a current perspective on chromosome wide gene regulation by non-coding RNAs.
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