Intrinsic defect of the immune system in children with Down syndrome: a review - PubMed (original) (raw)
Review
Intrinsic defect of the immune system in children with Down syndrome: a review
M A A Kusters et al. Clin Exp Immunol. 2009 May.
Abstract
Down syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and present results of immunological studies in DS children in relation to the clinical consequences they suffer, we conclude that it is more likely that the DS immune system is intrinsically deficient from the very beginning.
Similar articles
- Down syndrome B-lymphocyte subpopulations, intrinsic defect or decreased T-lymphocyte help.
Verstegen RH, Kusters MA, Gemen EF, DE Vries E. Verstegen RH, et al. Pediatr Res. 2010 May;67(5):563-9. doi: 10.1203/PDR.0b013e3181d4ecc1. Pediatr Res. 2010. PMID: 20098344 - Precocious aging of the immune system in Down syndrome: alteration of B lymphocytes, T-lymphocyte subsets, and cells with natural killer markers.
Cossarizza A, Monti D, Montagnani G, Ortolani C, Masi M, Zannotti M, Franceschi C. Cossarizza A, et al. Am J Med Genet Suppl. 1990;7:213-8. doi: 10.1002/ajmg.1320370743. Am J Med Genet Suppl. 1990. PMID: 2149950 - Autoantibodies in patients with Down syndrome: early senescence of the immune system or precocious markers for immunological diseases?
da Rosa Utiyama SR, Nisihara RM, Nass FR, Oliveira NP, Fiedler PT, de Messias-Reason IT. da Rosa Utiyama SR, et al. J Paediatr Child Health. 2008 Apr;44(4):182-6. doi: 10.1111/j.1440-1754.2007.01229.x. Epub 2007 Oct 10. J Paediatr Child Health. 2008. PMID: 17927730 - The Pattern of Malignancies in Down Syndrome and Its Potential Context With the Immune System.
Satgé D, Seidel MG. Satgé D, et al. Front Immunol. 2018 Dec 19;9:3058. doi: 10.3389/fimmu.2018.03058. eCollection 2018. Front Immunol. 2018. PMID: 30631328 Free PMC article. Review. - Immunology of Down syndrome: a review.
Ugazio AG, Maccario R, Notarangelo LD, Burgio GR. Ugazio AG, et al. Am J Med Genet Suppl. 1990;7:204-12. doi: 10.1002/ajmg.1320370742. Am J Med Genet Suppl. 1990. PMID: 2149949 Review.
Cited by
- Food protein-induced enteropathy: a revision for the clinician.
Barni S, Mori F, Pecoraro L, Saretta F, Giovannini M, Arasi S, Liotti L, Mastrorilli C, Klain A, Gelsomino M, Castagnoli R, Miraglia Del Giudice M, Novembre E. Barni S, et al. Front Pediatr. 2024 Sep 10;12:1417391. doi: 10.3389/fped.2024.1417391. eCollection 2024. Front Pediatr. 2024. PMID: 39318619 Free PMC article. Review. - General Dietary Recommendations for People with Down Syndrome.
Gruszka J, Włodarek D. Gruszka J, et al. Nutrients. 2024 Aug 11;16(16):2656. doi: 10.3390/nu16162656. Nutrients. 2024. PMID: 39203792 Free PMC article. Review. - Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome.
Liu J, Chen S, Huang G, Wen P, Zhou X, Wu Y. Liu J, et al. Cell Mol Life Sci. 2024 Mar 3;81(1):112. doi: 10.1007/s00018-024-05127-0. Cell Mol Life Sci. 2024. PMID: 38433139 Free PMC article. - Cytomegalovirus Pneumonia in a Patient with Down Syndrome.
Perrotta F, Piscopiello D, Rizzo D, Iosa G, Garzya G, Calò P, Gemma D. Perrotta F, et al. Medicina (Kaunas). 2024 Jan 30;60(2):242. doi: 10.3390/medicina60020242. Medicina (Kaunas). 2024. PMID: 38399530 Free PMC article. - Recurrent Respiratory Infections in Children with Down Syndrome: A Review.
Ghezzi M, Garancini N, De Santis R, Gianolio L, Zirpoli S, Mandelli A, Farolfi A, D'Auria E, Zuccotti GV. Ghezzi M, et al. Children (Basel). 2024 Feb 15;11(2):246. doi: 10.3390/children11020246. Children (Basel). 2024. PMID: 38397357 Free PMC article. Review.
References
- Hassold T, Jacobs P. Trisomy in man. Ann Rev Genet. 1984;18:69–97. - PubMed
- Lott I. Down's syndrome, aging, and Alzheimer's disease: a clinical review. Ann NY Acad Sci. 1982;396:15–27. - PubMed
- Tolksdorf M, Wiedemann H. Clinical aspects of Down's syndrome from infancy to adult life. Hum Genet Suppl. 1981;2:3–31. - PubMed
- Miller RW. Neoplasia and Down's syndrome. Ann NY Acad Sci. 1970;171:637.
- Fraumeni J, Manning M, Mitus W. Acute childhood leukemia: epidemiological study by cell type in 1263 cases at the Children's Cancer Research Foundation in Boston. J Natl Cancer Inst. 1971;46:461–70. - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous