Proton pump inhibitor failure--what are the therapeutic options? - PubMed (original) (raw)
Review
. 2009 Mar:104 Suppl 2:S33-8.
doi: 10.1038/ajg.2009.50.
Affiliations
- PMID: 19262545
- DOI: 10.1038/ajg.2009.50
Review
Proton pump inhibitor failure--what are the therapeutic options?
Ronnie Fass. Am J Gastroenterol. 2009 Mar.
Abstract
Proton pump inhibitor (PPI) failure is very common and may affect up to one-third of the PPI consumers. Identifying the underlying mechanisms for PPI failure in each individual patient is essential for treatment success. For residual acid reflux, increasing the PPI dose to twice daily; switching to another PPI, or adding an histamine 2 receptor antagonist could be a successful therapeutic strategy. In patients with duodenogastroesophageal reflux, weak acidic/alkaline reflux and hypersensitivity to acid reflux, therapeutic modalities that reduce transient lower esophageal sphincter relaxation or visceral pain could be entertained. Treatment of PPI failure due to delayed gastric emptying should be focused on improving gastric motor activity. Psychological management may supplement any medical or surgical approach toward PPI failure.
Similar articles
- Management of heartburn not responding to proton pump inhibitors.
Fass R, Sifrim D. Fass R, et al. Gut. 2009 Feb;58(2):295-309. doi: 10.1136/gut.2007.145581. Gut. 2009. PMID: 19136523 Review. - Therapeutic options for refractory gastroesophageal reflux disease.
Fass R. Fass R. J Gastroenterol Hepatol. 2012 Apr;27 Suppl 3:3-7. doi: 10.1111/j.1440-1746.2012.07064.x. J Gastroenterol Hepatol. 2012. PMID: 22486864 Review. - Management of gastroesophageal reflux disease that does not respond well to proton pump inhibitors.
Hershcovici T, Fass R. Hershcovici T, et al. Curr Opin Gastroenterol. 2010 Jul;26(4):367-78. doi: 10.1097/MOG.0b013e32833ae2be. Curr Opin Gastroenterol. 2010. PMID: 20571388 Review. - Comparison of the degree of duodenogastroesophageal reflux and acid reflux between patients who failed to respond and those who were successfully treated with a proton pump inhibitor once daily.
Gasiorowska A, Navarro-Rodriguez T, Wendel C, Krupinski E, Perry ZH, Koenig K, Moty B, Powers J, Fass R. Gasiorowska A, et al. Am J Gastroenterol. 2009 Aug;104(8):2005-13. doi: 10.1038/ajg.2009.240. Epub 2009 Jun 2. Am J Gastroenterol. 2009. PMID: 19491829 - Weakly acidic reflux.
Tack J, Blondeau K. Tack J, et al. Dig Dis. 2009;27(1):58-61. doi: 10.1159/000210105. Epub 2009 May 8. Dig Dis. 2009. PMID: 19439962 Review.
Cited by
- Efficacy and safety of HIP1601 (dual delayed-release esomeprazole) 40 mg in erosive esophagitis compared to HGP1705 (delayed-release esomeprazole) 40 mg: a multicenter, randomized, double-blind, non-inferiority study.
Lim H, Park JK, Chung H, Lee SH, Park JM, Park JH, Kim GH, Shin SK, Hong SJ, Lee KJ, Park MI, Jung HK, Kim HS, Sung JK, Jeon SW, Choi SC, Moon JS, Kim N, Park JJ, Hong SH, Kim NY, Jung HY. Lim H, et al. BMC Gastroenterol. 2023 Dec 18;23(1):447. doi: 10.1186/s12876-023-03087-6. BMC Gastroenterol. 2023. PMID: 38110901 Free PMC article. Clinical Trial. - Hypercontractile esophagus responsive to potassium-competitive acid blockers: a case report.
Shao Y, Xie C, Feng H, Yan D, Chen W. Shao Y, et al. BMC Gastroenterol. 2022 Jun 23;22(1):307. doi: 10.1186/s12876-022-02375-x. BMC Gastroenterol. 2022. PMID: 35739486 Free PMC article. - Consensus statements and recommendations on the management of mild-to-moderate gastroesophageal reflux disease in the Southeast Asian region.
Goh KL, Lee YY, Leelakusolvong S, Makmun D, Maneerattanaporn M, Quach DT, Raja Ali RA, Sollano JD, Tran VH, Wong RK. Goh KL, et al. JGH Open. 2021 Jul 31;5(8):855-863. doi: 10.1002/jgh3.12602. eCollection 2021 Aug. JGH Open. 2021. PMID: 34386592 Free PMC article. - Efficacy of different endoscopic treatments in patients with gastroesophageal reflux disease: a systematic review and network meta-analysis.
Xie P, Yan J, Ye L, Wang C, Li Y, Chen Y, Li G. Xie P, et al. Surg Endosc. 2021 Apr;35(4):1500-1510. doi: 10.1007/s00464-021-08386-1. Epub 2021 Mar 1. Surg Endosc. 2021. PMID: 33650003
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical