Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches - PubMed (original) (raw)

. 2009 Mar 13;323(5920):1488-92.

doi: 10.1126/science.1169152.

Affiliations

• PMID: 19286559
• DOI: 10.1126/science.1169152

Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches

Masayuki Tsuji et al. Science. 2009.

Abstract

Most of the immunoglobulin A (IgA) in the gut is generated by B cells in the germinal centers of Peyer's patches through a process that requires the presence of CD4+ follicular B helper T(TFH) cells. The nature of these T(FH) cells in Peyer's patches has been elusive. Here, we demonstrate that suppressive Foxp3+CD4+ T cells can differentiate into TFH cells in mouse Peyer's patches. The conversion of Foxp3+ T cells into TFH cells requires the loss of Foxp3 expression and subsequent interaction with B cells. Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells.

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Comment in

• Research highlights: Immunomodulation.
  Wada H, Kojo S, Seino K. Wada H, et al. Immunotherapy. 2009 Sep;1(5):737-9. doi: 10.2217/imt.09.49. Immunotherapy. 2009. PMID: 20636017 No abstract available.

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