Regulation of mammalian pre-mRNA splicing - PubMed (original) (raw)
Review
Regulation of mammalian pre-mRNA splicing
JingYi Hui. Sci China C Life Sci. 2009 Mar.
Abstract
In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins. Recent genome-wide analyses of alternative splicing indicated that in higher eukaryotes alternative splicing is an important mechanism that generates proteomic complexity and regulates gene expression. Mis-regulation of splicing causes a wide range of human diseases. This review describes the current understanding of pre-mRNA splicing and the mechanisms that regulate mammalian pre-mRNA splicing. It also discusses emerging directions in the field of alternative splicing.
Similar articles
- Plant serine/arginine-rich proteins and their role in pre-mRNA splicing.
Reddy AS. Reddy AS. Trends Plant Sci. 2004 Nov;9(11):541-7. doi: 10.1016/j.tplants.2004.09.007. Trends Plant Sci. 2004. PMID: 15501179 Review. - SR protein kinases: the splice of life.
Stojdl DF, Bell JC. Stojdl DF, et al. Biochem Cell Biol. 1999;77(4):293-8. Biochem Cell Biol. 1999. PMID: 10546892 Review. - Specificity in splicing.
Holliday R, Murray V. Holliday R, et al. Bioessays. 1994 Oct;16(10):771-4. doi: 10.1002/bies.950161013. Bioessays. 1994. PMID: 7980482 - Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing.
Shkreta L, Bell B, Revil T, Venables JP, Prinos P, Elela SA, Chabot B. Shkreta L, et al. Cancer Treat Res. 2013;158:41-94. doi: 10.1007/978-3-642-31659-3_3. Cancer Treat Res. 2013. PMID: 24222354 Review. - Non-coding functions of alternative pre-mRNA splicing in development.
Mockenhaupt S, Makeyev EV. Mockenhaupt S, et al. Semin Cell Dev Biol. 2015 Dec;47-48:32-9. doi: 10.1016/j.semcdb.2015.10.018. Epub 2015 Oct 19. Semin Cell Dev Biol. 2015. PMID: 26493705 Free PMC article. Review.
Cited by
- Modulation of OPRM1 Alternative Splicing by Morphine and HIV-1 Nef.
Donadoni M, Huang W, Yarandi SS, Burdo TH, Chang SL, Sariyer IK. Donadoni M, et al. J Neuroimmune Pharmacol. 2022 Jun;17(1-2):277-288. doi: 10.1007/s11481-021-10009-4. Epub 2021 Aug 21. J Neuroimmune Pharmacol. 2022. PMID: 34420144 Free PMC article. - Intron retention-dependent gene regulation in Cryptococcus neoformans.
Gonzalez-Hilarion S, Paulet D, Lee KT, Hon CC, Lechat P, Mogensen E, Moyrand F, Proux C, Barboux R, Bussotti G, Hwang J, Coppée JY, Bahn YS, Janbon G. Gonzalez-Hilarion S, et al. Sci Rep. 2016 Aug 31;6:32252. doi: 10.1038/srep32252. Sci Rep. 2016. PMID: 27577684 Free PMC article. - Morphine-induced MOR-1X and ASF/SF2 Expressions Are Independent of Transcriptional Regulation: Implications for MOR-1X Signaling.
Regan PM, Sariyer IK, Langford TD, Datta PK, Khalili K. Regan PM, et al. J Cell Physiol. 2016 Jul;231(7):1542-53. doi: 10.1002/jcp.25246. Epub 2015 Dec 28. J Cell Physiol. 2016. PMID: 26553431 Free PMC article. - Regulation and Functional Implications of Opioid Receptor Splicing in Opioid Pharmacology and HIV Pathogenesis.
Regan PM, Langford D, Khalili K. Regan PM, et al. J Cell Physiol. 2016 May;231(5):976-85. doi: 10.1002/jcp.25237. Epub 2015 Nov 24. J Cell Physiol. 2016. PMID: 26529364 Free PMC article. Review. - Coupling and coordination in gene expression processes with pre-mRNA splicing.
Pan K, Lee JT, Huang Z, Wong CM. Pan K, et al. Int J Mol Sci. 2015 Mar 11;16(3):5682-96. doi: 10.3390/ijms16035682. Int J Mol Sci. 2015. PMID: 25768347 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources