Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs? - PubMed (original) (raw)
Review
doi: 10.1007/s00280-009-0976-y. Epub 2009 Mar 18.
Affiliations
- PMID: 19294386
- DOI: 10.1007/s00280-009-0976-y
Free article
Review
Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?
Sarah Thomasset et al. Cancer Chemother Pharmacol. 2009 Jun.
Free article
Abstract
Anthocyanins, plant pigments in fruits and berries, have been shown to delay cancer development in rodent models of carcinogenesis, especially those of the colorectal tract. Anthocyanins and anthocyanidins, their aglycons, especially cyanidin and delphinidin, have been subjected to extensive mechanistic studies. In cells in vitro, both glycosides and aglycons engage an array of anti-oncogenic mechanisms including anti-proliferation, induction of apoptosis and inhibition of activities of oncogenic transcription factors and protein tyrosine kinases. Anthocyanins and anthocyanidins exist as four isomers, interconversion between which depends on pH, temperature and access to light. Anthocyanidins are much more prone to avid chemical decomposition than the glycosides, and they only survive for minutes in the biophase. These pharmaceutical issues are very important determinants of the suitability of these flavonoids for potential development as cancer chemopreventive drugs, and they have hitherto not received adequate attention. In the light of their robust cancer chemopreventive efficacy in experimental models and their superior stability as compared to that of the aglycons, the anthocyanins seem much more suitable for further drug development than their anthocyanidin counterparts.
Comment in
- Anthocyanins-based drugs for colon cancer treatment: the nutritionist's point of view.
Galvano F, Salamone F, Nicolosi A, Vitaglione P. Galvano F, et al. Cancer Chemother Pharmacol. 2009 Jul;64(2):431-2. doi: 10.1007/s00280-009-1025-6. Epub 2009 May 20. Cancer Chemother Pharmacol. 2009. PMID: 19455331 No abstract available.
Similar articles
- Anthocyans from fruits and vegetables--does bright colour signal cancer chemopreventive activity?
Cooke D, Steward WP, Gescher AJ, Marczylo T. Cooke D, et al. Eur J Cancer. 2005 Sep;41(13):1931-40. doi: 10.1016/j.ejca.2005.06.009. Eur J Cancer. 2005. PMID: 16084717 Review. - Delphinidin and Its Glycosides' War on Cancer: Preclinical Perspectives.
Sharma A, Choi HK, Kim YK, Lee HJ. Sharma A, et al. Int J Mol Sci. 2021 Oct 25;22(21):11500. doi: 10.3390/ijms222111500. Int J Mol Sci. 2021. PMID: 34768930 Free PMC article. Review. - Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.
Hou DX, Kai K, Li JJ, Lin S, Terahara N, Wakamatsu M, Fujii M, Young MR, Colburn N. Hou DX, et al. Carcinogenesis. 2004 Jan;25(1):29-36. doi: 10.1093/carcin/bgg184. Epub 2003 Sep 26. Carcinogenesis. 2004. PMID: 14514663 - The Promising Therapeutic and Preventive Properties of Anthocyanidins/Anthocyanins on Prostate Cancer.
Mottaghipisheh J, Doustimotlagh AH, Irajie C, Tanideh N, Barzegar A, Iraji A. Mottaghipisheh J, et al. Cells. 2022 Mar 22;11(7):1070. doi: 10.3390/cells11071070. Cells. 2022. PMID: 35406634 Free PMC article. Review. - Anthocyanidins induce apoptosis in human promyelocytic leukemia cells: structure-activity relationship and mechanisms involved.
Hou DX, Ose T, Lin S, Harazoro K, Imamura I, Kubo M, Uto T, Terahara N, Yoshimoto M, Fujii M. Hou DX, et al. Int J Oncol. 2003 Sep;23(3):705-12. Int J Oncol. 2003. PMID: 12888907
Cited by
- Advances in the Chemistry, Analysis and Adulteration of Anthocyanin Rich-Berries and Fruits: 2000-2022.
Avula B, Katragunta K, Osman AG, Ali Z, John Adams S, Chittiboyina AG, Khan IA. Avula B, et al. Molecules. 2023 Jan 5;28(2):560. doi: 10.3390/molecules28020560. Molecules. 2023. PMID: 36677615 Free PMC article. Review. - Phytochemicals for the Prevention and Treatment of Renal Cell Carcinoma: Preclinical and Clinical Evidence and Molecular Mechanisms.
Bajalia EM, Azzouz FB, Chism DA, Giansiracusa DM, Wong CG, Plaskett KN, Bishayee A. Bajalia EM, et al. Cancers (Basel). 2022 Jul 4;14(13):3278. doi: 10.3390/cancers14133278. Cancers (Basel). 2022. PMID: 35805049 Free PMC article. Review. - Consumption of anthocyanin-rich beverages affects Nrf2 and Nrf2-dependent gene transcription in peripheral lymphocytes and DNA integrity of healthy volunteers.
Groh IAM, Bakuradze T, Pahlke G, Richling E, Marko D. Groh IAM, et al. BMC Chem. 2020 May 29;14(1):39. doi: 10.1186/s13065-020-00690-6. eCollection 2020 Dec. BMC Chem. 2020. PMID: 32514500 Free PMC article. - Genetic and Comparative Transcriptome Analysis Revealed DEGs Involved in the Purple Leaf Formation in Brassica juncea.
Heng S, Wang L, Yang X, Huang H, Chen G, Cui M, Liu M, Lv Q, Wan Z, Shen J, Fu T. Heng S, et al. Front Genet. 2020 Apr 24;11:322. doi: 10.3389/fgene.2020.00322. eCollection 2020. Front Genet. 2020. PMID: 32391051 Free PMC article. - Transcriptional regulation of anthocyanin biosynthesis in a high-anthocyanin resynthesized Brassica napus cultivar.
Goswami G, Nath UK, Park JI, Hossain MR, Biswas MK, Kim HT, Kim HR, Nou IS. Goswami G, et al. J Biol Res (Thessalon). 2018 Nov 26;25:19. doi: 10.1186/s40709-018-0090-6. eCollection 2018 Dec. J Biol Res (Thessalon). 2018. PMID: 30505808 Free PMC article.