De novo expression of the neurokinin 1 receptor in spinal lamina I pyramidal neurons in polyarthritis - PubMed (original) (raw)
. 2009 May 20;514(3):284-95.
doi: 10.1002/cne.22024.
Affiliations
- PMID: 19296480
- DOI: 10.1002/cne.22024
De novo expression of the neurokinin 1 receptor in spinal lamina I pyramidal neurons in polyarthritis
L Almarestani et al. J Comp Neurol. 2009.
Abstract
Spinal lamina I (LI) neurons play a major role in the transmission and integration of pain-related information that is relayed to higher centers. Alterations in the excitability of these neurons influence chronic pain development, and expression of the neurokinin 1 receptor (NK-1r) is thought to play a major role in such changes. Novel expression of NK-1r may underlie hyperexcitability in new populations of LI neurons. LI projection neurons can be classified morphologically into fusiform, pyramidal, and multipolar cells, differing in their functional properties, with the pyramidal type being nonnociceptive. In agreement with this, we have shown that spinoparabrachial pyramidal neurons seldom express NK-1r, in contrast with the other two cell types. In this study we investigated in the rat the long-term changes in NK-1r expression by spinoparabrachial LI neurons following the unilateral injection in the hindpaw plantar surface of complete Freund's adjuvant (CFA). Cholera toxin subunit B (CTb) was injected unilaterally into the parabrachial nucleus. Our results revealed that, ipsilaterally, pyramidal neurons were seldom immunoreactive for NK-1r both in saline-injected and in CFA-injected rats, up to 10 days post-CFA. However, a considerable number of pyramidal cells were immunoreactive for NK-1r at 15, 21, and 30 days post-CFA. Our data raise the possibility -- which needs to be confirmed by electrophysiology -- that most LI projection neurons of the pyramidal type are likely nonnociceptive in naive animals but might become nociceptive following the development of arthritis.
Similar articles
- Morphological characterization of spinal cord dorsal horn lamina I neurons projecting to the parabrachial nucleus in the rat.
Almarestani L, Waters SM, Krause JE, Bennett GJ, Ribeiro-da-Silva A. Almarestani L, et al. J Comp Neurol. 2007 Sep 20;504(3):287-97. doi: 10.1002/cne.21410. J Comp Neurol. 2007. PMID: 17640051 - De novo expression of neurokinin-1 receptors by spinoparabrachial lamina I pyramidal neurons following a peripheral nerve lesion.
Saeed AW, Ribeiro-da-Silva A. Saeed AW, et al. J Comp Neurol. 2013 Jun 1;521(8):1915-28. doi: 10.1002/cne.23267. J Comp Neurol. 2013. PMID: 23172292 - Morphology and neurokinin 1 receptor expression of spinothalamic lamina I neurons in the rat spinal cord.
Yu XH, Ribeiro-da-Silva A, De Koninck Y. Yu XH, et al. J Comp Neurol. 2005 Oct 10;491(1):56-68. doi: 10.1002/cne.20675. J Comp Neurol. 2005. PMID: 16127696 - The role of peptides in central sensitization.
Seybold VS. Seybold VS. Handb Exp Pharmacol. 2009;(194):451-91. doi: 10.1007/978-3-540-79090-7_13. Handb Exp Pharmacol. 2009. PMID: 19655115 Review. - A role for substance P in arthritis?
Keeble JE, Brain SD. Keeble JE, et al. Neurosci Lett. 2004 May 6;361(1-3):176-9. doi: 10.1016/j.neulet.2003.12.020. Neurosci Lett. 2004. PMID: 15135922 Review.
Cited by
- Substance P and pain chronicity.
Zieglgänsberger W. Zieglgänsberger W. Cell Tissue Res. 2019 Jan;375(1):227-241. doi: 10.1007/s00441-018-2922-y. Epub 2018 Oct 3. Cell Tissue Res. 2019. PMID: 30284083 Free PMC article. Review. - Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain.
Wu CH, Yuan XC, Gao F, Li HP, Cao J, Liu YS, Yu W, Tian B, Meng XF, Shi J, Pan HL, Li M. Wu CH, et al. Mol Neurobiol. 2016 Oct;53(8):5640-51. doi: 10.1007/s12035-015-9482-x. Epub 2015 Oct 19. Mol Neurobiol. 2016. PMID: 26482371 - Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers.
Saeed AW, Pawlowski SA, Ribeiro-da-Silva A. Saeed AW, et al. Mol Pain. 2015 Sep 9;11:54. doi: 10.1186/s12990-015-0060-z. Mol Pain. 2015. PMID: 26353788 Free PMC article. - Transmitting pain and itch messages: a contemporary view of the spinal cord circuits that generate gate control.
Braz J, Solorzano C, Wang X, Basbaum AI. Braz J, et al. Neuron. 2014 May 7;82(3):522-36. doi: 10.1016/j.neuron.2014.01.018. Neuron. 2014. PMID: 24811377 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous