Transplantation for cholangiocarcinoma: when and for whom? - PubMed (original) (raw)

Review

. 2009 Apr;18(2):325-37, ix.

doi: 10.1016/j.soc.2008.12.008.

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Review

Transplantation for cholangiocarcinoma: when and for whom?

David J Rea et al. Surg Oncol Clin N Am. 2009 Apr.

Abstract

Liver transplantation for cholangiocarcinoma has historically been maligned. Because of a high recurrence rate and poor patient survival, the disease has been viewed as an absolute contraindication to transplantation. Based on good results using neoadjuvant and palliative radiation, a protocol for liver transplantation in selected patients with unresectable hilar cholangiocarcinoma was developed in 1993. Neoadjuvant radiation is followed by operative staging to rule out patients with lymph node metastases before liver transplantation. This approach has achieved results superior to standard surgical therapy, with 72% 5-year survival for patients with unresectable disease.

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