Parallel progression of primary tumours and metastases - PubMed (original) (raw)

Review

doi: 10.1038/nrc2627.

Affiliations

• PMID: 19308069
• DOI: 10.1038/nrc2627

Review

Parallel progression of primary tumours and metastases

Christoph A Klein. Nat Rev Cancer. 2009 Apr.

Abstract

Systemic cancer progression is accounted for in two basic models. The prevailing archetype places the engine of cancer progression within the primary tumour before metastatic dissemination of fully malignant cells. The second posits parallel, independent progression of metastases arising from early disseminated tumour cells. This Perspective draws together data from disease courses, tumour growth rates, autopsy studies, clinical trials and molecular genetic analyses of primary and disseminated tumour cells in support of the parallel progression model. Consideration of this model urges review of current diagnostic and therapeutic routines.

PubMed Disclaimer

Comment in

• Parallel progression of tumour and metastases.
  Koscielny S, Tubiana M. Koscielny S, et al. Nat Rev Cancer. 2010 Feb;10(2):156. doi: 10.1038/nrc2627-c1. Nat Rev Cancer. 2010. PMID: 20094050 No abstract available.

Similar articles

• Genetic disparity between primary tumours, disseminated tumour cells, and manifest metastasis.
  Stoecklein NH, Klein CA. Stoecklein NH, et al. Int J Cancer. 2010 Feb 1;126(3):589-98. doi: 10.1002/ijc.24916. Int J Cancer. 2010. PMID: 19795462 Review.
• [From single disseminated tumor cells to metastasis insights from molecular genetic analyses of single cells].
  Klein CA. Klein CA. Verh Dtsch Ges Pathol. 2003;87:158-64. Verh Dtsch Ges Pathol. 2003. PMID: 16888908 German.
• Selection and adaptation during metastatic cancer progression.
  Klein CA. Klein CA. Nature. 2013 Sep 19;501(7467):365-72. doi: 10.1038/nature12628. Nature. 2013. PMID: 24048069
• Using tumour phylogenetics to identify the roots of metastasis in humans.
  Naxerova K, Jain RK. Naxerova K, et al. Nat Rev Clin Oncol. 2015 May;12(5):258-72. doi: 10.1038/nrclinonc.2014.238. Epub 2015 Jan 20. Nat Rev Clin Oncol. 2015. PMID: 25601447 Review.
• Integrated molecular and clinical staging defines the spectrum of metastatic cancer.
  Pitroda SP, Weichselbaum RR. Pitroda SP, et al. Nat Rev Clin Oncol. 2019 Sep;16(9):581-588. doi: 10.1038/s41571-019-0220-6. Nat Rev Clin Oncol. 2019. PMID: 31092903 Review.

Cited by

• A robust method to analyze copy number alterations of less than 100 kb in single cells using oligonucleotide array CGH.
  Möhlendick B, Bartenhagen C, Behrens B, Honisch E, Raba K, Knoefel WT, Stoecklein NH. Möhlendick B, et al. PLoS One. 2013 Jun 25;8(6):e67031. doi: 10.1371/journal.pone.0067031. Print 2013. PLoS One. 2013. PMID: 23825608 Free PMC article.
• Generalized principles of stochasticity can be used to control dynamic heterogeneity.
  Liao D, Estévez-Salmerón L, Tlsty TD. Liao D, et al. Phys Biol. 2012 Dec;9(6):065006. doi: 10.1088/1478-3975/9/6/065006. Epub 2012 Nov 29. Phys Biol. 2012. PMID: 23197162 Free PMC article.
• [Surgical treatment of skeletal metastases].
  Gösling T, Becker-Schiebe M. Gösling T, et al. Unfallchirurg. 2015 Apr;118(4):347-63. doi: 10.1007/s00113-015-2742-4. Unfallchirurg. 2015. PMID: 25835208 German.
• NRAS mutations in primary and metastatic melanomas of Japanese patients.
  Uhara H, Ashida A, Koga H, Ogawa E, Uchiyama A, Uchiyama R, Hayashi K, Kiniwa Y, Okuyama R. Uhara H, et al. Int J Clin Oncol. 2014;19(3):544-8. doi: 10.1007/s10147-013-0573-2. Epub 2013 Jun 6. Int J Clin Oncol. 2014. PMID: 23739925
• Occult urothelial carcinoma with mediastinal metastasis: A case report.
  Zheng J, Peng X, Li X, Chen Y, Li X, Fu L, Li A, Lu Z. Zheng J, et al. Oncol Lett. 2024 Feb 9;27(4):148. doi: 10.3892/ol.2024.14281. eCollection 2024 Apr. Oncol Lett. 2024. PMID: 38385116 Free PMC article.

References

1. 1. Clin Cancer Res. 1999 Oct;5(10):2820-3 - PubMed
2. 1. Cell. 2008 Jun 13;133(6):994-1005 - PubMed
3. 1. Cancer Cell. 2004 Jun;5(6):525-31 - PubMed
4. 1. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2246-51 - PubMed
5. 1. J Natl Cancer Inst. 1993 Sep 1;85(17):1419-24 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database