Integrins as mechanochemical transducers - PubMed (original) (raw)
Review
Integrins as mechanochemical transducers
D Ingber. Curr Opin Cell Biol. 1991 Oct.
Abstract
A recent resurgence of interest in mechanical forces and cell shape as biological regulators has revealed extracellular matrix as the site at which forces are transmitted both to and from cells. at the same time, great advances have been made in terms of defining cell-surface integrin receptors as transmembrane molecules that mediate cell attachment and physically interlink extracellular matrix with the intracellular cytoskeleton. Convergence of these two lines of research has begun to elucidate the molecular mechanism by which cells sense physical forces and transduce mechanical signals into a biochemical response.
Similar articles
- Integrins, tensegrity, and mechanotransduction.
Ingber DE. Ingber DE. Gravit Space Biol Bull. 1997 Jun;10(2):49-55. Gravit Space Biol Bull. 1997. PMID: 11540119 Review. - Integrins and regulation of the microcirculation: from arterioles to molecular studies using atomic force microscopy.
Martinez-Lemus LA, Sun Z, Trache A, Trzciakowski JP, Meininger GA. Martinez-Lemus LA, et al. Microcirculation. 2005 Jan-Feb;12(1):99-112. doi: 10.1080/10739680590896054. Microcirculation. 2005. PMID: 15804978 Review. - [Roles of integrins and cytoskeleton in cellular mechanotransduction].
Yang F, Li YH. Yang F, et al. Space Med Med Eng (Beijing). 2002 Aug;15(4):309-12. Space Med Med Eng (Beijing). 2002. PMID: 12425342 Review. Chinese. - Tensegrity: the architectural basis of cellular mechanotransduction.
Ingber DE. Ingber DE. Annu Rev Physiol. 1997;59:575-99. doi: 10.1146/annurev.physiol.59.1.575. Annu Rev Physiol. 1997. PMID: 9074778 Review. - Integrins and mechanotransduction of the vascular myogenic response.
Davis MJ, Wu X, Nurkiewicz TR, Kawasaki J, Davis GE, Hill MA, Meininger GA. Davis MJ, et al. Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1427-33. doi: 10.1152/ajpheart.2001.280.4.H1427. Am J Physiol Heart Circ Physiol. 2001. PMID: 11247750 Review.
Cited by
- Lung parenchymal mechanics.
Suki B, Stamenović D, Hubmayr R. Suki B, et al. Compr Physiol. 2011 Jul;1(3):1317-51. doi: 10.1002/cphy.c100033. Compr Physiol. 2011. PMID: 23733644 Free PMC article. Review. - Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle.
McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK. McCain ML, et al. Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9881-6. doi: 10.1073/pnas.1203007109. Epub 2012 Jun 6. Proc Natl Acad Sci U S A. 2012. PMID: 22675119 Free PMC article. - The tumor microenvironment is a dominant force in multidrug resistance.
Correia AL, Bissell MJ. Correia AL, et al. Drug Resist Updat. 2012 Feb-Apr;15(1-2):39-49. doi: 10.1016/j.drup.2012.01.006. Epub 2012 Feb 13. Drug Resist Updat. 2012. PMID: 22335920 Free PMC article. Review. - Engineered materials and the cellular microenvironment: a strengthening interface between cell biology and bioengineering.
Choi CK, Breckenridge MT, Chen CS. Choi CK, et al. Trends Cell Biol. 2010 Dec;20(12):705-14. doi: 10.1016/j.tcb.2010.09.007. Epub 2010 Oct 20. Trends Cell Biol. 2010. PMID: 20965727 Free PMC article. Review. - Effect of angiotensin II blockade on central blood pressure and arterial stiffness in subjects with hypertension.
Safar ME. Safar ME. Int J Nephrol Renovasc Dis. 2010;3:167-73. doi: 10.2147/IJNRD.S6664. Epub 2010 Dec 3. Int J Nephrol Renovasc Dis. 2010. PMID: 21694942 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources