Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge - PubMed (original) (raw)

Topically applied recombinant chemokine analogues fully protect macaques from vaginal simian-human immunodeficiency virus challenge

Ronald S Veazey et al. J Infect Dis. 2009.

Abstract

Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.

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Figures

Figure 1

Full protection of macaques against vaginal simian-human immunodeficiency virus (SHIV) challenge by intravaginal pretreatment with recombinant chemokine analogues. Thirty minutes before challenge with 300 TCID50 of SHIV162P3, animals were treated with either PBS or RANTES analogues at 1 mmol/L. They were then monitored regularly for plasma viremia for 10 weeks.

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