Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007 - PubMed (original) (raw)

Concurrent chikungunya and dengue virus infections during simultaneous outbreaks, Gabon, 2007

Eric M Leroy et al. Emerg Infect Dis. 2009 Apr.

Abstract

An outbreak of febrile illness occurred in Gabon in 2007, with 20,000 suspected cases. Chikungunya or dengue-2 virus infections were identified in 321 patients; 8 patients had documented co-infections. Aedes albopictus was identified as the principal vector for the transmission of both viruses.

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Figures

Figure 1

Figure 1

Chikungunya and dengue outbreaks in Gabon, 2007. Distribution of the outbreak and location of the 7 towns where suspected cases have been laboratory confirmed by using quantitative reverse transcription–PCR assay are shown. Chikungunya cases are represented by red circles, dengue cases by blue circles, and cases negative for the viruses by green circles. Testing methods are described in the footnote to the Table.

Figure 2

Figure 2

Phylogenetic relationships among dengue-2 virus (DENV-2) isolates based on full-length sequences (10,695 nt). A total of 85 DENV-2 genomes were compared with the human isolate obtained during the Gabon outbreak. Phylogeny was inferred by using neighbor-joining analysis. A neighbor-joining tree was constructed by using MEGA version 3.2 (

www.megasoftware.net

) with the Kimura 2-parameter corrections of multiple substitutions. Reliability of nodes was assessed by bootstrap resampling with 1,000 replicates. Branches are scaled according the number of substitutions per site, and the branch leading to the Thailand 94 strain was shortened for convenience. Bootstrap values are shown for major key nodes.

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