Blood lactate is an important energy source for the human brain - PubMed (original) (raw)
Blood lactate is an important energy source for the human brain
Gerrit van Hall et al. J Cereb Blood Flow Metab. 2009 Jun.
Abstract
Lactate is a potential energy source for the brain. The aim of this study was to establish whether systemic lactate is a brain energy source. We measured in vivo cerebral lactate kinetics and oxidation rates in 6 healthy individuals at rest with and without 90 mins of intravenous lactate infusion (36 mumol per kg bw per min), and during 30 mins of cycling exercise at 75% of maximal oxygen uptake while the lactate infusion continued to establish arterial lactate concentrations of 0.89+/-0.08, 3.9+/-0.3, and 6.9+/-1.3 mmol/L, respectively. At rest, cerebral lactate utilization changed from a net lactate release of 0.06+/-0.01 to an uptake of 0.16+/-0.07 mmol/min during lactate infusion, with a concomitant decrease in the net glucose uptake. During exercise, the net cerebral lactate uptake was further increased to 0.28+/-0.16 mmol/min. Most (13)C-label from cerebral [1-(13)C]lactate uptake was released as (13)CO(2) with 100%+/-24%, 86%+/-15%, and 87%+/-30% at rest with and without lactate infusion and during exercise, respectively. The contribution of systemic lactate to cerebral energy expenditure was 8%+/-2%, 19%+/-4%, and 27%+/-4% for the respective conditions. In conclusion, systemic lactate is taken up and oxidized by the human brain and is an important substrate for the brain both under basal and hyperlactatemic conditions.
Similar articles
- Leg and arm lactate and substrate kinetics during exercise.
Van Hall G, Jensen-Urstad M, Rosdahl H, Holmberg HC, Saltin B, Calbet JA. Van Hall G, et al. Am J Physiol Endocrinol Metab. 2003 Jan;284(1):E193-205. doi: 10.1152/ajpendo.00273.2002. Epub 2002 Sep 11. Am J Physiol Endocrinol Metab. 2003. PMID: 12388120 - Brain oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not sufficient to offset energy deficit.
Lubow JM, Piñón IG, Avogaro A, Cobelli C, Treeson DM, Mandeville KA, Toffolo G, Boyle PJ. Lubow JM, et al. Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E149-E153. doi: 10.1152/ajpendo.00049.2005. Epub 2005 Sep 6. Am J Physiol Endocrinol Metab. 2006. PMID: 16144821 - Cerebral glucose and lactate consumption during cerebral activation by physical activity in humans.
Rasmussen P, Wyss MT, Lundby C. Rasmussen P, et al. FASEB J. 2011 Sep;25(9):2865-73. doi: 10.1096/fj.11-183822. Epub 2011 May 20. FASEB J. 2011. PMID: 21602451 - Lactate fuels the human brain during exercise.
Quistorff B, Secher NH, Van Lieshout JJ. Quistorff B, et al. FASEB J. 2008 Oct;22(10):3443-9. doi: 10.1096/fj.08-106104. Epub 2008 Jul 24. FASEB J. 2008. PMID: 18653766 Review. - Fuelling cerebral activity in exercising man.
Dalsgaard MK. Dalsgaard MK. J Cereb Blood Flow Metab. 2006 Jun;26(6):731-50. doi: 10.1038/sj.jcbfm.9600256. J Cereb Blood Flow Metab. 2006. PMID: 16395281 Review.
Cited by
- Arterial to jugular-bulb lactate difference in patients undergoing elective brain tumor craniotomy.
Vassilieva A, Olsen MH, Skjøth-Rasmussen J, Møller K, Sørensen MK. Vassilieva A, et al. Physiol Rep. 2024 Oct;12(20):e70084. doi: 10.14814/phy2.70084. Physiol Rep. 2024. PMID: 39414383 Free PMC article. - High-intensity interval training reduces Tau and beta-amyloid accumulation by improving lactate-dependent mitophagy in rats with type 2 diabetes.
Khosravi P, Shahidi F, Eskandari A, Khoramipour K. Khosravi P, et al. Iran J Basic Med Sci. 2024;27(11):1430-1439. doi: 10.22038/ijbms.2024.77038.16664. Iran J Basic Med Sci. 2024. PMID: 39386233 Free PMC article. - From starvation to time-restricted eating: a review of fasting physiology.
Rebello CJ, Zhang D, Anderson JC, Bowman RF, Peeke PM, Greenway FL. Rebello CJ, et al. Int J Obes (Lond). 2024 Oct 5. doi: 10.1038/s41366-024-01641-0. Online ahead of print. Int J Obes (Lond). 2024. PMID: 39369112 Review. - Modern Perspective of Lactate Metabolism.
Vavřička J, Brož P, Follprecht D, Novák J, Kroužecký A. Vavřička J, et al. Physiol Res. 2024 Aug 31;73(4):499-514. doi: 10.33549/physiolres.935331. Physiol Res. 2024. PMID: 39264074 Free PMC article. Review. - A neurometabolic mechanism involving dmPFC/dACC lactate in physical effort-based decision-making.
Clairis N, Barakat A, Brochard J, Xin L, Sandi C. Clairis N, et al. Mol Psychiatry. 2024 Aug 30. doi: 10.1038/s41380-024-02726-y. Online ahead of print. Mol Psychiatry. 2024. PMID: 39215184
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources