Assessing the validity of current mouse genetic models of obsessive-compulsive disorder - PubMed (original) (raw)

Review

Assessing the validity of current mouse genetic models of obsessive-compulsive disorder

Li Wang et al. Behav Pharmacol. 2009 Mar.

Abstract

Obsessive-compulsive disorder (OCD) is a disorder characterized by unwanted and intrusive thoughts, images, or impulses and/or repetitive behavior. OCD is a major cause of disability; however, the genetic factors and pathophysiological mechanisms underlying this complex, heterogeneous disorder remain largely unknown. During the past decade, a number of putative mouse genetic models of OCD have been developed for the purpose of studying the neural mechanisms underlying this disorder and developing novel treatments. This review presents and evaluates these experimental preparations to date. Models using knockout or transgenic approaches, as well as those examining variation in genetically diverse populations, are evaluated and discussed.

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Conflict of interest statement

All authors declare that there are no personal financial holdings that could be perceived as constituting a potential conflict of interest.

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Assessing the validity of current mouse genetic models of obsessive-compulsive disorder - PubMed (original) (raw)