Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem - PubMed (original) (raw)
Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem
Scott A Weisenberg et al. Diagn Microbiol Infect Dis. 2009 Jun.
Abstract
Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae may appear susceptible to imipenem or meropenem by routine susceptibility testing. We report a series of patients with infections caused by K. pneumoniae isolates, which yielded imipenem-susceptible results but were subsequently KPC-positive by polymerase chain reaction. When these infections were treated with imipenem or meropenem, frequent clinical and microbiologic failures were observed.
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References
- Bradford PA, Bratu S, Urban C, Visalli M, Mariano N, Landman D, Rahal JJ, Brooks S, Cebular S, Quale J. Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City. Clin Infect Dis. 2004;39:55–60. - PubMed
- Bratu S, Landman D, Haag R, Recco R, Eramo A, Alam M, Quale J. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: A new threat to our antibiotic armamentarium. Arch Intern Med. 2005;165:1430. - PubMed
- Deshpande LM, Rhomberg PR, Sader HS, Jones RN. Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States medical centers: Report from the MYSTIC program (1999-2005) Diagn Microb and Infect Dis. 2006;56:367–72. - PubMed
- Espinal-Witter R, Casal CE, Fauntleroy KA, Larone DH. Detection of Klebsiella pneumoniae Carbapenemase (KPC) by Vitek 2 AST GN Card Using Ertapenem as the Indicator. Abstracts of the American Society of Microbiology Annual Meeting; Toronto, Canada. May 21-25, 2007; 2007. Abstract C-044.
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