Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem - PubMed (original) (raw)

Clinical outcomes of patients with Klebsiella pneumoniae carbapenemase-producing K. pneumoniae after treatment with imipenem or meropenem

Scott A Weisenberg et al. Diagn Microbiol Infect Dis. 2009 Jun.

Abstract

Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae may appear susceptible to imipenem or meropenem by routine susceptibility testing. We report a series of patients with infections caused by K. pneumoniae isolates, which yielded imipenem-susceptible results but were subsequently KPC-positive by polymerase chain reaction. When these infections were treated with imipenem or meropenem, frequent clinical and microbiologic failures were observed.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Anderson KF, Lonsway DR, Rasheed JK, Biddle J, Jenson B, McDougal LK, Carey RB, Thompson A, Stocker S, Limbago B, Patel JB. Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae. J Clin Microbiol. 2007;45:2723–5. - PMC - PubMed
    1. Bradford PA, Bratu S, Urban C, Visalli M, Mariano N, Landman D, Rahal JJ, Brooks S, Cebular S, Quale J. Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City. Clin Infect Dis. 2004;39:55–60. - PubMed
    1. Bratu S, Landman D, Haag R, Recco R, Eramo A, Alam M, Quale J. Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: A new threat to our antibiotic armamentarium. Arch Intern Med. 2005;165:1430. - PubMed
    1. Deshpande LM, Rhomberg PR, Sader HS, Jones RN. Emergence of serine carbapenemases (KPC and SME) among clinical strains of Enterobacteriaceae isolated in the United States medical centers: Report from the MYSTIC program (1999-2005) Diagn Microb and Infect Dis. 2006;56:367–72. - PubMed
    1. Espinal-Witter R, Casal CE, Fauntleroy KA, Larone DH. Detection of Klebsiella pneumoniae Carbapenemase (KPC) by Vitek 2 AST GN Card Using Ertapenem as the Indicator. Abstracts of the American Society of Microbiology Annual Meeting; Toronto, Canada. May 21-25, 2007; 2007. Abstract C-044.

MeSH terms

Substances

Grants and funding

LinkOut - more resources