Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation - PubMed (original) (raw)
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doi: 10.1038/nri2536.
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- PMID: 19365409
- DOI: 10.1038/nri2536
Review
Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation
Gabriel A Rabinovich et al. Nat Rev Immunol. 2009 May.
Abstract
The function of deciphering the biological information encoded by the glycome, which is the entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in part to endogenous glycan-binding proteins or lectins. Galectins, a family of animal lectins that bind N-acetyllactosamine-containing glycans, have many roles in diverse immune cell processes, including those relevant to pathogen recognition, shaping the course of adaptive immune responses and fine-tuning the inflammatory response. How do galectins translate glycan-encoded information into tolerogenic or inflammatory cell programmes? An improved understanding of the mechanisms underlying these functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
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