The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats - PubMed (original) (raw)
Comparative Study
. 2009 Nov;12(10):1355-66.
doi: 10.1017/S1461145709000273. Epub 2009 Apr 15.
Affiliations
- PMID: 19366487
- DOI: 10.1017/S1461145709000273
Free article
Comparative Study
The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats
Kelly J Clemens et al. Int J Neuropsychopharmacol. 2009 Nov.
Free article
Abstract
Several minor tobacco alkaloids have been found to exhibit properties pharmacologically relevant to the addictive profile of tobacco; however, little is known of their effects on a behavioural model of drug addiction. In this study we compared the locomotor and reinforcing effects of intravenous nicotine (30 microg/kg per infusion) vs. a cocktail of nicotine plus five minor alkaloids found in tobacco smoke (anabasine, nornicotine, anatabine, cotinine and myosmine). Rats were initially tested for their locomotor response to nicotine or nicotine plus the minor alkaloids with six intravenous injections over 1 h. We then assessed the spontaneous acquisition of intravenous self-administration with nicotine or nicotine plus the minor alkaloids, under a fixed-ratio 1 schedule followed by responding on a fixed-ratio 5 schedule, progressive-ratio schedule and a single within-session ascending dose-response test. The activity test was repeated following the progressive-ratio phase to assess locomotor sensitization. A second group of rats were then tested on the locomotor procedure to better clarify the role of each individual minor alkaloid in nicotine-induced locomotor activity. Compared to nicotine alone, addition of the minor tobacco alkaloids increased locomotor activity and increased locomotor sensitization following self-administration. During fixed-ratio 5, progressive ratio and the dose-response test, rats receiving nicotine plus the minor alkaloids responded significantly more than those receiving nicotine alone. Testing of each minor alkaloid in the second experiment indicated that anatabine, cotinine and myosmine individually increased nicotine-induced locomotor activity. These results suggest that the minor tobacco alkaloids, particularly anatabine, cotinine and myosmine, may increase the motivation for nicotine and thus facilitate smoking behaviour.
Similar articles
- Effects of isolated tobacco alkaloids and tobacco products on deprivation-induced food intake and meal patterns in rats.
Bunney PE, Hansen M, LeSage M. Bunney PE, et al. Pharmacol Biochem Behav. 2018 Feb;165:45-55. doi: 10.1016/j.pbb.2017.11.004. Epub 2017 Nov 28. Pharmacol Biochem Behav. 2018. PMID: 29196096 Free PMC article. - Determination of behaviorally effective tobacco constituent doses in rats.
Wiley JL, Marusich JA, Thomas BF, Jackson KJ. Wiley JL, et al. Nicotine Tob Res. 2015 Mar;17(3):368-71. doi: 10.1093/ntr/ntu194. Epub 2014 Sep 30. Nicotine Tob Res. 2015. PMID: 25271188 Free PMC article. - Nicotine-like behavioral effects of the minor tobacco alkaloids nornicotine, anabasine, and anatabine in male rodents.
Caine SB, Collins GT, Thomsen M, Wright C, Lanier RK, Mello NK. Caine SB, et al. Exp Clin Psychopharmacol. 2014 Feb;22(1):9-22. doi: 10.1037/a0035749. Exp Clin Psychopharmacol. 2014. PMID: 24490708 - Depressing time: Waiting, melancholia, and the psychoanalytic practice of care.
Salisbury L, Baraitser L. Salisbury L, et al. In: Kirtsoglou E, Simpson B, editors. The Time of Anthropology: Studies of Contemporary Chronopolitics. Abingdon: Routledge; 2020. Chapter 5. In: Kirtsoglou E, Simpson B, editors. The Time of Anthropology: Studies of Contemporary Chronopolitics. Abingdon: Routledge; 2020. Chapter 5. PMID: 36137063 Free Books & Documents. Review. - Pharmacological treatments in panic disorder in adults: a network meta-analysis.
Guaiana G, Meader N, Barbui C, Davies SJ, Furukawa TA, Imai H, Dias S, Caldwell DM, Koesters M, Tajika A, Bighelli I, Pompoli A, Cipriani A, Dawson S, Robertson L. Guaiana G, et al. Cochrane Database Syst Rev. 2023 Nov 28;11(11):CD012729. doi: 10.1002/14651858.CD012729.pub3. Cochrane Database Syst Rev. 2023. PMID: 38014714 Free PMC article. Review.
Cited by
- Route of administration effects on nicotine discrimination in female and male mice.
Lefever TW, Thomas BF, Kovach AL, Snyder RW, Wiley JL. Lefever TW, et al. Drug Alcohol Depend. 2019 Nov 1;204:107504. doi: 10.1016/j.drugalcdep.2019.06.007. Epub 2019 Aug 24. Drug Alcohol Depend. 2019. PMID: 31476643 Free PMC article. - Anabasine and Anatabine Exposure Attributable to Cigarette Smoking: National Health and Nutrition Examination Survey (NHANES) 2013-2014.
Bendik PB, Rutt SM, Pine BN, Sosnoff CS, Blount BC, Zhu W, Feng J, Wang L. Bendik PB, et al. Int J Environ Res Public Health. 2022 Aug 8;19(15):9744. doi: 10.3390/ijerph19159744. Int J Environ Res Public Health. 2022. PMID: 35955098 Free PMC article. - Nicotine-, tobacco particulate matter- and methamphetamine-produced locomotor sensitisation in rats.
Brennan KA, Putt F, Truman P. Brennan KA, et al. Psychopharmacology (Berl). 2013 Aug;228(4):659-72. doi: 10.1007/s00213-013-3071-3. Epub 2013 Mar 22. Psychopharmacology (Berl). 2013. PMID: 23519574 - Nicotine vaccines to assist with smoking cessation: current status of research.
Raupach T, Hoogsteder PH, Onno van Schayck CP. Raupach T, et al. Drugs. 2012 Mar 5;72(4):e1-16. doi: 10.2165/11599900-000000000-00000. Drugs. 2012. PMID: 22356293 Free PMC article. Review. - Nicotine reduction revisited: science and future directions.
Hatsukami DK, Perkins KA, Lesage MG, Ashley DL, Henningfield JE, Benowitz NL, Backinger CL, Zeller M. Hatsukami DK, et al. Tob Control. 2010 Oct;19(5):e1-10. doi: 10.1136/tc.2009.035584. Tob Control. 2010. PMID: 20876072 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources