Resolving the relationship between ApolipoproteinE and depression - PubMed (original) (raw)

Resolving the relationship between ApolipoproteinE and depression

Michael A Slifer et al. Neurosci Lett. 2009.

Abstract

Several studies have reported an association between the ApolipoproteinE-epsilon4 (APOE4) allele and depression among elders. However others have failed to find an association. Since APOE4 is a well recognized risk factor for Alzheimer dementia, cognitive status may represent an important confounder between APOE4 and depression. In this investigation, we examined the relationship between the ApolipoproteinE-epsilon4 allele and depression among elders accounting for cognitive status. Using a case-control design (n=1052), we investigated the association between ApolipoproteinE-epsilon4 and depression in Alzheimer disease patients (n=528) and in cognitively intact controls (n=524). We demonstrated an apparent association between the APOE4 allele and depression in the combined dataset (p=0.001) when not controlling for cognitive status. However, once stratified by the presence of Alzheimer disease, there was no association in either the Alzheimer group (p=0.290) or the cognitively intact controls (p=0.494). In this dataset there is no association between the ApolipoproteinE-epsilon4 allele and depression among those with Alzheimer disease or among cognitively intact elders. However there is a significant association between female gender and depression in the cognitively intact (p=0.003) but not among those with Alzheimer disease. Additionally, individuals with Alzheimer disease and depression had a significantly younger age of onset for their Alzheimer disease than those without depression (p=0.017).

PubMed Disclaimer

Similar articles

• Depression and plasma amyloid beta peptides in the elderly with and without the apolipoprotein E4 allele.
  Sun X, Chiu CC, Liebson E, Crivello NA, Wang L, Claunch J, Folstein M, Rosenberg I, Mwamburi DM, Peter I, Qiu WQ. Sun X, et al. Alzheimer Dis Assoc Disord. 2009 Jul-Sep;23(3):238-44. doi: 10.1097/WAD.0b013e31819cb3ac. Alzheimer Dis Assoc Disord. 2009. PMID: 19812466 Free PMC article.
• Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.
  Belloy ME, Napolioni V, Han SS, Le Guen Y, Greicius MD; Alzheimer’s Disease Neuroimaging Initiative. Belloy ME, et al. JAMA Neurol. 2020 Jul 1;77(7):849-862. doi: 10.1001/jamaneurol.2020.0414. JAMA Neurol. 2020. PMID: 32282020 Free PMC article.
• Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease.
  Fleisher AS, Chen K, Liu X, Ayutyanont N, Roontiva A, Thiyyagura P, Protas H, Joshi AD, Sabbagh M, Sadowsky CH, Sperling RA, Clark CM, Mintun MA, Pontecorvo MJ, Coleman RE, Doraiswamy PM, Johnson KA, Carpenter AP, Skovronsky DM, Reiman EM. Fleisher AS, et al. Neurobiol Aging. 2013 Jan;34(1):1-12. doi: 10.1016/j.neurobiolaging.2012.04.017. Epub 2012 May 24. Neurobiol Aging. 2013. PMID: 22633529
• Interaction of Cigarette Smoking History With APOE Genotype and Age on Amyloid Level, Glucose Metabolism, and Neurocognition in Cognitively Normal Elders.
  Durazzo TC, Mattsson N, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative. Durazzo TC, et al. Nicotine Tob Res. 2016 Feb;18(2):204-11. doi: 10.1093/ntr/ntv075. Epub 2015 Apr 6. Nicotine Tob Res. 2016. PMID: 25847292 Free PMC article.
• Neuroimaging biomarkers for Alzheimer's disease in asymptomatic APOE4 carriers.
  Chételat G, Fouquet M. Chételat G, et al. Rev Neurol (Paris). 2013 Oct;169(10):729-36. doi: 10.1016/j.neurol.2013.07.025. Epub 2013 Sep 6. Rev Neurol (Paris). 2013. PMID: 24016463 Review.

Cited by

• Associations of APOE ε4 With Health and Financial Literacy Among Community-Based Older Adults Without Dementia.
  Stewart CC, Boyle PA, James BD, Yu L, Han SD, Bennett DA. Stewart CC, et al. J Gerontol B Psychol Sci Soc Sci. 2018 Jun 14;73(5):778-786. doi: 10.1093/geronb/gbw054. J Gerontol B Psychol Sci Soc Sci. 2018. PMID: 27174891 Free PMC article.
• Determinants of behavioral and psychological symptoms of dementia: A scoping review of the evidence.
  Kolanowski A, Boltz M, Galik E, Gitlin LN, Kales HC, Resnick B, Van Haitsma KS, Knehans A, Sutterlin JE, Sefcik JS, Liu W, Petrovsky DV, Massimo L, Gilmore-Bykovskyi A, MacAndrew M, Brewster G, Nalls V, Jao YL, Duffort N, Scerpella D. Kolanowski A, et al. Nurs Outlook. 2017 Sep-Oct;65(5):515-529. doi: 10.1016/j.outlook.2017.06.006. Epub 2017 Jun 16. Nurs Outlook. 2017. PMID: 28826872 Free PMC article. Review.
• Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype.
  Barberger-Gateau P, Samieri C, Féart C, Plourde M. Barberger-Gateau P, et al. Curr Alzheimer Res. 2011 Aug;8(5):479-91. doi: 10.2174/156720511796391926. Curr Alzheimer Res. 2011. PMID: 21605054 Free PMC article. Review.
• Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan.
  Burns RA, Andrews S, Cherbuin N, Anstey KJ. Burns RA, et al. BJPsych Open. 2020 May 8;6(3):e47. doi: 10.1192/bjo.2020.29. BJPsych Open. 2020. PMID: 32381152 Free PMC article.
• The genetics of major depression: moving beyond the monoamine hypothesis.
  Shyn SI, Hamilton SP. Shyn SI, et al. Psychiatr Clin North Am. 2010 Mar;33(1):125-40. doi: 10.1016/j.psc.2009.10.004. Psychiatr Clin North Am. 2010. PMID: 20159343 Free PMC article. Review.

References

1. 1. Alexopoulos GS. Role of executive function in late-life depression. Journal of Clinical Psychiatry. 2003;64(suppl 14):18–23. - PubMed
2. 1. Beekman AT, Copeland JR, Prince MJ. Review of community prevalence of depression in later life. Br J Psychiatry. 1999;174:307–311. - PubMed
3. 1. Broe GA, Henderson AS, Creasey H, McCusker E, Korten AE, Jorm AF, et al. A case-control study of Alzheimer’s disease in Australia. Neurology. 1990;40:1698–1707. - PubMed
4. 1. Cacabelos R, Rodriguez B, Carrera C, Beyer K, Lao JI, Sellers MA. Behavioral changes associated with different apolipoprotein E genotypes in dementia. Alzheimer Dis Assoc Disord. 1997;11(Suppl 4):S27–S34. - PubMed
5. 1. Cantillon M, Harwood D, Barker W, St George-Hyslop P, Tsuda T, Ekatarina R, et al. No association between apolipoprotein E genotype and late-onset depression in Alzheimer’s disease. Biol Psychiatry. 1997;41:246–248. - PubMed

Publication types

MeSH terms

Substances

Grants and funding

• R01 AG021547-05/AG/NIA NIH HHS/United States
• R01 AG19757/AG/NIA NIH HHS/United States
• R01 NS31153/NS/NINDS NIH HHS/United States
• R01 NS031153/NS/NINDS NIH HHS/United States
• R01 AG020135-06/AG/NIA NIH HHS/United States
• R01 AG20135/AG/NIA NIH HHS/United States
• R01 AG019757-06/AG/NIA NIH HHS/United States
• M01 RR000095-47/RR/NCRR NIH HHS/United States
• M01 RR000095/RR/NCRR NIH HHS/United States
• R01 NS031153-14/NS/NINDS NIH HHS/United States
• R01 AG020135/AG/NIA NIH HHS/United States
• R01 AG021547/AG/NIA NIH HHS/United States
• R01 AG019757/AG/NIA NIH HHS/United States

LinkOut - more resources

• Full Text Sources

  • Elsevier Science
  • Europe PubMed Central
  • PubMed Central

• Medical

  • MedlinePlus Health Information