The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Why empirical therapy? - PubMed (original) (raw)

Review

. 2009 May:63 Suppl 1:i14-5.

doi: 10.1093/jac/dkp075.

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Review

The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Why empirical therapy?

Jean Klastersky. J Antimicrob Chemother. 2009 May.

Abstract

Why empirical therapy? Because it works! Empirical antimicrobial therapy is a reasonable, pragmatic approach to limit the ominous threat of Gram-negative sepsis in febrile neutropenic cancer patients. Empirical treatment of occult fungal infection in patients with neutropenia and persistent fever, in spite of initial broad-spectrum antimicrobial coverage, is effective but the role of pre-emptive treatment remains to be established.

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