A randomized controlled trial of cervical scanning vs history to determine cerclage in women at high risk of preterm birth (CIRCLE trial) - PubMed (original) (raw)
Randomized Controlled Trial
. 2009 Jun;200(6):623.e1-6.
doi: 10.1016/j.ajog.2009.03.010. Epub 2009 Apr 19.
Affiliations
- PMID: 19380124
- DOI: 10.1016/j.ajog.2009.03.010
Randomized Controlled Trial
A randomized controlled trial of cervical scanning vs history to determine cerclage in women at high risk of preterm birth (CIRCLE trial)
Rachael Simcox et al. Am J Obstet Gynecol. 2009 Jun.
Abstract
Objective: We sought to compare history-indicated placement of cervical cerclage based on history- vs ultrasound-indicated placement in women at risk of preterm birth.
Study design: We conducted a randomized controlled trial of history-indicated cervical cerclage suture based on history (clinician preference) vs ultrasound (< 20 mm cervical length) indicated in women at increased risk.
Results: The incidence of the primary outcome, preterm delivery between 24(+0) and 33(+6) weeks, was similar: 19/125 (15%) in the history-indicated group vs 18/122 (15%) in the ultrasound-indicated group (relative risk [RR], 0.97; 95% confidence interval [CI], 0.54-1.76). Those women randomized to the ultrasound-indicated arm were significantly more likely to receive a cerclage (32% vs 19%; RR, 1.66; 95% CI, 1.07-2.47) and progesterone (39% vs 25%; RR, 1.55; 95% CI, 1.06-2.25).
Conclusion: Screening women at high risk with cervical ultrasound to determine cerclage placement results in more intervention but similar outcome compared with history-indicated placement.
Comment in
- Don't be fooled by Simcox CIRCLE.
Andrews J. Andrews J. Am J Obstet Gynecol. 2010 Feb;202(2):e4; author reply e4-5. doi: 10.1016/j.ajog.2009.08.023. Epub 2009 Nov 4. Am J Obstet Gynecol. 2010. PMID: 19889383 No abstract available.
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