Immunotherapy: Vaccine trials in melanoma -- time for reflection - PubMed (original) (raw)
Comment
Immunotherapy: Vaccine trials in melanoma -- time for reflection
Alexander M M Eggermont. Nat Rev Clin Oncol. 2009 May.
Abstract
The disappointing results of the large, randomized, controlled trials showing no benefit of vaccines in patients with advanced and metastatic melanoma call for a reassessment of the development of therapeutic vaccines and the importance of better immune monitoring methodology, such as adoptive T-cell therapy with lymphodepletion.
Comment on
- Adoptive cell transfer: a clinical path to effective cancer immunotherapy.
Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME. Rosenberg SA, et al. Nat Rev Cancer. 2008 Apr;8(4):299-308. doi: 10.1038/nrc2355. Nat Rev Cancer. 2008. PMID: 18354418 Free PMC article. Review.
References
- Br J Cancer. 1987 Aug;56(2):97-102 - PubMed
- J Clin Oncol. 2001 May 1;19(9):2370-80 - PubMed
- J Clin Oncol. 2008 May 10;26(14):2292-8 - PubMed
- Nat Rev Cancer. 2008 Apr;8(4):299-308 - PubMed
- Clin Cancer Res. 2008 Sep 1;14(17):5610-8 - PubMed
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