Beclin 1: a BH3-only protein that fails to induce apoptosis - PubMed (original) (raw)
Comment
. 2009 May 28;28(21):2125-7.
doi: 10.1038/onc.2009.83. Epub 2009 Apr 27.
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- PMID: 19398951
- DOI: 10.1038/onc.2009.83
Comment
Beclin 1: a BH3-only protein that fails to induce apoptosis
P Boya et al. Oncogene. 2009.
Abstract
Beclin 1 has been recently shown to possess a Bcl-2 homology-3 (BH3) domain that mediates its interaction with antiapoptotic multidomain proteins. Unlike other BH3-only proteins, Beclin 1 fails to stimulate apoptosis when it is overexpressed. In this issue of Oncogene, Ciechomska et al. report the intriguing finding that Bcl-2, as it interacts with Beclin 1, does not lose its anti-apoptotic potential. This finding may have far-reaching implications for the comprehension of the cross-talk between apoptosis and autophagy.
Comment on
- Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function.
Ciechomska IA, Goemans GC, Skepper JN, Tolkovsky AM. Ciechomska IA, et al. Oncogene. 2009 May 28;28(21):2128-41. doi: 10.1038/onc.2009.60. Epub 2009 Apr 6. Oncogene. 2009. PMID: 19347031
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