Effects of stress throughout the lifespan on the brain, behaviour and cognition - PubMed (original) (raw)
Review
doi: 10.1038/nrn2639. Epub 2009 Apr 29.
Affiliations
- PMID: 19401723
- DOI: 10.1038/nrn2639
Review
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Sonia J Lupien et al. Nat Rev Neurosci. 2009 Jun.
Abstract
Chronic exposure to stress hormones, whether it occurs during the prenatal period, infancy, childhood, adolescence, adulthood or aging, has an impact on brain structures involved in cognition and mental health. However, the specific effects on the brain, behaviour and cognition emerge as a function of the timing and the duration of the exposure, and some also depend on the interaction between gene effects and previous exposure to environmental adversity. Advances in animal and human studies have made it possible to synthesize these findings, and in this Review a model is developed to explain why different disorders emerge in individuals exposed to stress at different times in their lives.
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