The sequence-structure relationship and protein function prediction - PubMed (original) (raw)
Review
The sequence-structure relationship and protein function prediction
M I Sadowski et al. Curr Opin Struct Biol. 2009 Jun.
Abstract
An incomplete understanding of protein sequence/structure/function relationships causes many difficulties for prediction methods. The highly complex nature of these relationships is a consequence of the interplay between physics and evolution that has been studied using a wide array of experimental and theoretical techniques. We review recent findings relating to conservation of sequence, structure and function and discuss their use in developing improved prediction methods.
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