Adult neurogenesis promotes synaptic plasticity in the olfactory bulb - PubMed (original) (raw)

doi: 10.1038/nn.2298. Epub 2009 May 3.

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• PMID: 19412168
• DOI: 10.1038/nn.2298

Adult neurogenesis promotes synaptic plasticity in the olfactory bulb

Antoine Nissant et al. Nat Neurosci. 2009 Jun.

Abstract

To explore the functional consequences of adult neurogenesis in the mouse olfactory bulb, we investigated plasticity at glutamatergic synapses onto GABAergic interneurons. We found that one subset of excitatory synapses onto adult-born granule cells showed long-term potentiation shortly after their arrival in the bulb. This property faded as the newborn neurons matured. These results indicate that recently generated adult-born olfactory interneurons undergo different experience-dependent synaptic modifications compared with their pre-existing mature neighbors and provide a possible substrate for adult neurogenesis-dependent olfactory learning.

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References

1. 1. Nat Rev Neurosci. 2006 Mar;7(3):179-93 - PubMed
2. 1. J Comp Neurol. 1981 Dec 10;203(3):475-93 - PubMed
3. 1. Biophys J. 1991 Nov;60(5):1288-94 - PubMed
4. 1. J Neurosci. 2008 Nov 5;28(45):11511-6 - PubMed
5. 1. Neuron. 2007 May 24;54(4):559-66 - PubMed

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