Defective interfering particles with covalently linked [+/-]RNA induce interferon - PubMed (original) (raw)
. 1977 Apr 28;266(5605):815-9.
doi: 10.1038/266815a0.
- PMID: 194158
- DOI: 10.1038/266815a0
Defective interfering particles with covalently linked [+/-]RNA induce interferon
P I Marcus et al. Nature. 1977.
Abstract
Defective interfering (DI) particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [-]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon. A single particle can induce a quantum yield of interferon. A single molecule of double-stranded RNA presumed to form, at least in part, on entry into the cell is thought to induce interferon synthesis. Conventional [-]RNA DI particles with the same polypeptide composition as [+/-]RNA DI particles fail to induce interferon.
Similar articles
- Synthesis of a small RNA in cells coinfected by standard and defective interfering particles of vesicular stomatitis virus.
Rao DD, Huang AS. Rao DD, et al. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3742-5. doi: 10.1073/pnas.76.8.3742. Proc Natl Acad Sci U S A. 1979. PMID: 226977 Free PMC article. - Mechanisms of vesicular stomatitis virus-induced cytopathic effects. I. Early morphologic changes induced by infectious and defective-interfering particles.
Baxt B, Bablanian R. Baxt B, et al. Virology. 1976 Jul 15;72(2):370-82. doi: 10.1016/0042-6822(76)90166-5. Virology. 1976. PMID: 181906 No abstract available. - RNA polymerase-associated interactions near template promoter sequences of defective interfering particles of vesicular stomatitis virus.
Isaac CL, Keene JD. Isaac CL, et al. J Virol. 1982 Jul;43(1):241-9. doi: 10.1128/JVI.43.1.241-249.1982. J Virol. 1982. PMID: 6286999 Free PMC article. - Cell killing by viruses--single-cell survival procedure for detecting viral functions required for cell killing.
Marcus PI. Marcus PI. Adv Pathobiol. 1977;(6):192-213. Adv Pathobiol. 1977. PMID: 70984 Review. No abstract available. - Electron microscopy of viral RNA.
Meyer J. Meyer J. Curr Top Microbiol Immunol. 1981;94-95:209-41. doi: 10.1007/978-3-642-68120-2_5. Curr Top Microbiol Immunol. 1981. PMID: 6171389 Review. No abstract available.
Cited by
- Interferon induction and/or production and its suppression by influenza A viruses.
Marcus PI, Rojek JM, Sekellick MJ. Marcus PI, et al. J Virol. 2005 Mar;79(5):2880-90. doi: 10.1128/JVI.79.5.2880-2890.2005. J Virol. 2005. PMID: 15709007 Free PMC article. - Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad-spectrum antivirals?
Dimmock NJ, Easton AJ. Dimmock NJ, et al. J Virol. 2014 May;88(10):5217-27. doi: 10.1128/JVI.03193-13. Epub 2014 Feb 26. J Virol. 2014. PMID: 24574404 Free PMC article. Review. - An RNA editor, adenosine deaminase acting on double-stranded RNA (ADAR1).
George CX, John L, Samuel CE. George CX, et al. J Interferon Cytokine Res. 2014 Jun;34(6):437-46. doi: 10.1089/jir.2014.0001. J Interferon Cytokine Res. 2014. PMID: 24905200 Free PMC article. Review. - Inhibition of Innate Immune Responses Is Key to Pathogenesis by Arenaviruses.
Meyer B, Ly H. Meyer B, et al. J Virol. 2016 Mar 28;90(8):3810-3818. doi: 10.1128/JVI.03049-15. Print 2016 Apr. J Virol. 2016. PMID: 26865707 Free PMC article. Review. - In vitro analysis of virus particle subpopulations in candidate live-attenuated influenza vaccines distinguishes effective from ineffective vaccines.
Marcus PI, Ngunjiri JM, Sekellick MJ, Wang L, Lee CW. Marcus PI, et al. J Virol. 2010 Nov;84(21):10974-81. doi: 10.1128/JVI.00502-10. Epub 2010 Aug 25. J Virol. 2010. PMID: 20739541 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources