No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration - PubMed (original) (raw)
No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration
Sara Rollinson et al. Neurobiol Aging. 2011 Apr.
Abstract
Frontotemporal lobar degeneration (FTLD) is a highly familial neurodegenerative disease. It has been claimed that homozygosity of the SNP rs5848 located in the 3'UTR of progranulin increases risk for FTLD. We have attempted to replicate the association of rs5848 in three independent FTLD cohorts. No association of rs5848 with FTLD was observed in any individual cohort nor was any observed when the data was combined. These data argue that rs5848 is not a risk factor for FTLD.
Copyright © 2009 Elsevier Inc. All rights reserved.
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- MC_U123192748/MRC_/Medical Research Council/United Kingdom
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