Recombinant soluble human FcgammaR1A (CD64A) reduces inflammation in murine collagen-induced arthritis - PubMed (original) (raw)

. 2009 Jun 1;182(11):7272-9.

doi: 10.4049/jimmunol.0803497.

Nels Hamacher, Brandon Harder, Ken Bannink, Thomas R Bukowski, Kelly Byrnes-Blake, Sara Underwood, Colleen Oliver, Kimberly S Waggie, Claire Noriega, LuAnne Hebb, Mark W Rixon, Katherine E Lewis

Affiliations

• PMID: 19454724
• DOI: 10.4049/jimmunol.0803497

Recombinant soluble human FcgammaR1A (CD64A) reduces inflammation in murine collagen-induced arthritis

Jeff L Ellsworth et al. J Immunol. 2009.

Abstract

Binding of immune complexes to cellular FcgammaRs can promote cell activation and inflammation. In previous studies, a recombinant human (rh) soluble FcgammaR, rh-FcgammaRIA (CD64A), was shown to block inflammation in passive transfer models of immune complex-mediated disease. To assess whether rh-FcgammaRIA could block inflammation in a T cell- and B cell-dependent model of immune complex-mediated disease, the efficacy of rh-FcgammaRIA in collagen-induced arthritis was evaluated. Mice with established arthritis were treated with a single s.c. injection of rh-FcgammaRIA (0.2-2.0 mg/dose) given every other day for 11 days. Relative to mice injected with vehicle alone, mice treated with rh-FcgammaRIA exhibited lower serum concentrations of IL-6, anti-type II collagen Abs, and total IgG2a. These changes were correlated with lower levels of paw swelling and joint damage in the rh-FcgammaRIA-treated mice and occurred in the presence of a significant murine Ab response to rh-FcgammaRIA. Comparison of the serum rh-FcgammaRIA concentration vs time profiles for rh-FcgammaRIA administered at two dose levels by i.v. and s.c. injection revealed that the bioavailabilty of s.c. administered rh-FcgammaRIA was 27-37%. Taken together, these data show that rh-FcgammaRIA is an effective inhibitor of inflammation in a model of established arthritis in mice.

PubMed Disclaimer

Similar articles

• Targeting immune complex-mediated hypersensitivity with recombinant soluble human FcgammaRIA (CD64A).
  Ellsworth JL, Maurer M, Harder B, Hamacher N, Lantry M, Lewis KB, Rene S, Byrnes-Blake K, Underwood S, Waggie KS, Visich J, Lewis KE. Ellsworth JL, et al. J Immunol. 2008 Jan 1;180(1):580-9. doi: 10.4049/jimmunol.180.1.580. J Immunol. 2008. PMID: 18097060
• Generation of a high-affinity Fcgamma receptor by Ig-domain swapping between human CD64A and CD16A.
  Ellsworth JL, Hamacher N, Harder B, Maurer M, Bukowski TR, Lantry M, Noriega C, Rixon MW, Fox B, Lewis K, Meengs B, Rollins E, Greeff K, Meyer J, Birks C. Ellsworth JL, et al. Protein Eng Des Sel. 2010 Apr;23(4):299-309. doi: 10.1093/protein/gzq007. Epub 2010 Feb 11. Protein Eng Des Sel. 2010. PMID: 20150179
• Amelioration of collagen-induced arthritis by human recombinant soluble FcgammaRIIb.
  Magnusson SE, Andrén M, Nilsson KE, Sondermann P, Jacob U, Kleinau S. Magnusson SE, et al. Clin Immunol. 2008 May;127(2):225-33. doi: 10.1016/j.clim.2008.02.002. Epub 2008 Mar 17. Clin Immunol. 2008. PMID: 18346938
• Low-affinity Fcgamma receptors, autoimmunity and infection.
  Willcocks LC, Smith KG, Clatworthy MR. Willcocks LC, et al. Expert Rev Mol Med. 2009 Aug 13;11:e24. doi: 10.1017/S1462399409001161. Expert Rev Mol Med. 2009. PMID: 19674504 Review.
• [Prostaglandins, inflammation and arthritis].
  Floman Y, Naor Z, Zor U. Floman Y, et al. Harefuah. 1976 Mar 15;90(6):277-9. Harefuah. 1976. PMID: 776755 Review. Hebrew. No abstract available.

Cited by

• The solution structure of the unbound IgG Fc receptor CD64 resembles its crystal structure: Implications for function.
  Hui GK, Gao X, Gor J, Lu J, Sun PD, Perkins SJ. Hui GK, et al. PLoS One. 2023 Sep 21;18(9):e0288351. doi: 10.1371/journal.pone.0288351. eCollection 2023. PLoS One. 2023. PMID: 37733670 Free PMC article.
• Targeting the high affinity receptor, FcγRI, in autoimmune disease, neuropathy, and cancer.
  Holtrop T, Budding K, Brandsma AM, Leusen JHW. Holtrop T, et al. Immunother Adv. 2022 May 28;2(1):ltac011. doi: 10.1093/immadv/ltac011. eCollection 2022. Immunother Adv. 2022. PMID: 36284837 Free PMC article. Review.
• Sensory Neuron Expressed FcγRI Mediates Postinflammatory Arthritis Pain in Female Mice.
  Liu Y, Caterina MJ, Qu L. Liu Y, et al. Front Immunol. 2022 Jun 27;13:889286. doi: 10.3389/fimmu.2022.889286. eCollection 2022. Front Immunol. 2022. PMID: 35833115 Free PMC article.
• Autoimmune regulation of chronic pain.
  Lacagnina MJ, Heijnen CJ, Watkins LR, Grace PM. Lacagnina MJ, et al. Pain Rep. 2021 Mar 9;6(1):e905. doi: 10.1097/PR9.0000000000000905. eCollection 2021. Pain Rep. 2021. PMID: 33981931 Free PMC article. Review.
• Neuronal FcγRI mediates acute and chronic joint pain.
  Wang L, Jiang X, Zheng Q, Jeon SM, Chen T, Liu Y, Kulaga H, Reed R, Dong X, Caterina MJ, Qu L. Wang L, et al. J Clin Invest. 2019 Jun 18;129(9):3754-3769. doi: 10.1172/JCI128010. J Clin Invest. 2019. PMID: 31211699 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information