The amyloid hypothesis for Alzheimer's disease: a critical reappraisal - PubMed (original) (raw)

Review

. 2009 Aug;110(4):1129-34.

doi: 10.1111/j.1471-4159.2009.06181.x. Epub 2009 May 18.

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• PMID: 19457065
• DOI: 10.1111/j.1471-4159.2009.06181.x

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Review

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

John Hardy. J Neurochem. 2009 Aug.

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Abstract

The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-beta precursor protein (APP) and think how this may relate to the cell death in the disease process.

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