Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats - PubMed (original) (raw)
Quantitative analyses of matrix metalloproteinase activity after traumatic brain injury in adult rats
Takuro Hayashi et al. Brain Res. 2009.
Abstract
Recent laboratory evidence implicates matrix metalloproteinases (MMPs) as playing a pivotal role in ischemic and traumatic brain injuries (TBI). Here, quantitative real-time PCR analyses revealed that brains from TBI rats displayed significantly elevated MMP-9 expression at 24 h post-TBI, which remained upregulated at least until 48 h after injury. Immunohistochemical analyses similarly revealed significantly increased MMP-9 immunoreactivity at 24 and 48 h post-TBI. These results demonstrate that alterations in MMPs (i.e., MMP-9) commenced immediately after TBI, suggesting that treatment strategies designed to maintain MMP integrity should be initiated in the acute phase of injury.
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