Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells - PubMed (original) (raw)

doi: 10.1038/ni.1737. Epub 2009 May 24.

Affiliations

Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells

Tomohiro Yoshimoto et al. Nat Immunol. 2009 Jul.

Abstract

Basophils express major histocompatibility complex class II, CD80 and CD86 and produce interleukin 4 (IL-4) in various conditions. Here we show that when incubated with IL-3 and antigen or complexes of antigen and immunoglobulin E (IgE), basophils internalized, processed and presented antigen as complexes of peptide and major histocompatibility complex class II and produced IL-4. Intravenous administration of ovalbumin-pulsed basophils into naive mice 'preferentially' induced the development of naive ovalbumin-specific CD4+ T cells into T helper type 2 (T(H)2) cells. Mice immunized in this way, when challenged by intravenous administration of ovalbumin, promptly produced ovalbumin-specific IgG1 and IgE. Finally, intravenous administration of IgE complexes rapidly induced T(H)2 cells only in the presence of endogenous basophils, which suggests that basophils are potent antigen-presenting cells that 'preferentially' augment T(H)2-IgE responses by capturing IgE complex.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Exp Med. 2004 Aug 16;200(4):507-17 - PubMed
    1. Nat Rev Immunol. 2003 Feb;3(2):133-46 - PubMed
    1. Immunity. 2004 Mar;20(3):267-77 - PubMed
    1. Cytokine Growth Factor Rev. 2001 Mar;12(1):53-72 - PubMed
    1. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13962-6 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources