Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study - PubMed (original) (raw)
Comparative Study
Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study
Jeffrey L Ebersole et al. J Periodontol. 2009 Jun.
Abstract
Background: Our previous studies reported on the obstetric, periodontal, and microbiologic outcomes of women participating in the Obstetrics and Periodontal Therapy (OPT) Study. This article describes the systemic antibody responses to selected periodontal bacteria in the same patients.
Methods: Serum samples, obtained from pregnant women at baseline (13 to 16 weeks; 6 days of gestation) and 29 to 32 weeks, were analyzed by enzyme-linked immunosorbent assay for serum immunoglobulin G (IgG) antibody to Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Campylobacter rectus, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia (previously T. forsythensis), and Treponema denticola.
Results: At baseline, women who delivered live preterm infants had significantly lower total serum levels of IgG antibody to the panel of periodontal pathogens (P = 0.0018), to P. gingivalis (P = 0.0013), and to F. nucleatum (P = 0.0200) than women who delivered at term. These differences were not significant at 29 to 32 weeks. Changes in IgG levels between baseline and 29 to 32 weeks were not associated with preterm birth when adjusted for treatment group, clinical center, race, or age. In addition, delivery of low birth weight infants was not associated with levels of antibody at baseline or with antibody changes during pregnancy.
Conclusions: Live preterm birth is associated with decreased levels of IgG antibody to periodontal pathogens in women with periodontitis when assessed during the second trimester. Changes in IgG antibody during pregnancy are not associated with birth outcomes.
Conflict of interest statement
The authors report no conflicts of interest related to this study.
Similar articles
- Periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study.
Novak MJ, Novak KF, Hodges JS, Kirakodu S, Govindaswami M, Diangelis A, Buchanan W, Papapanou PN, Michalowicz BS. Novak MJ, et al. J Periodontol. 2008 Oct;79(10):1870-9. doi: 10.1902/jop.2008.070554. J Periodontol. 2008. PMID: 18834241 Clinical Trial. - Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure.
Madianos PN, Lieff S, Murtha AP, Boggess KA, Auten RL Jr, Beck JD, Offenbacher S. Madianos PN, et al. Ann Periodontol. 2001 Dec;6(1):175-82. doi: 10.1902/annals.2001.6.1.175. Ann Periodontol. 2001. PMID: 11887461 - Periodontitis in pregnant baboons: systemic inflammation and adaptive immune responses and pregnancy outcomes in a baboon model.
Ebersole JL, Holt SC, Cappelli D. Ebersole JL, et al. J Periodontal Res. 2014 Apr;49(2):226-36. doi: 10.1111/jre.12099. Epub 2013 May 28. J Periodontal Res. 2014. PMID: 23710643 Free PMC article. - [Research progress of correlation between periodontal pathogens and systemic diseases].
Du Q, Ma X. Du Q, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2020 May 30;40(5):759-764. doi: 10.12122/j.issn.1673-4254.2020.05.24. Nan Fang Yi Ke Da Xue Xue Bao. 2020. PMID: 32897213 Free PMC article. Review. Chinese. - An update on possible alternative therapeutics for future periodontal disease management.
Das V, Vinod V, Biswas L, Kumar A, Biswas R. Das V, et al. J Appl Microbiol. 2023 Jan 23;134(1):lxac039. doi: 10.1093/jambio/lxac039. J Appl Microbiol. 2023. PMID: 36724261 Review.
Cited by
- Association between periodontal disease, bacterial vaginosis, and sexual risk behaviours.
Zabor EC, Klebanoff M, Yu K, Zhang J, Nansel T, Andrews W, Schwebke J, Jeffcoat M. Zabor EC, et al. J Clin Periodontol. 2010 Oct;37(10):888-93. doi: 10.1111/j.1600-051X.2010.01593.x. J Clin Periodontol. 2010. PMID: 20636412 Free PMC article. - Periodontal health and pregnancy outcomes: Time to deliver.
Bostanci N. Bostanci N. Acta Obstet Gynecol Scand. 2023 Jun;102(6):648-651. doi: 10.1111/aogs.14548. Acta Obstet Gynecol Scand. 2023. PMID: 37212520 Free PMC article. No abstract available. - Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery.
Ye C, Xia Z, Tang J, Khemwong T, Kapila Y, Kuraji R, Huang P, Wu Y, Kobayashi H. Ye C, et al. Sci Rep. 2020 Sep 25;10(1):15807. doi: 10.1038/s41598-020-72807-9. Sci Rep. 2020. PMID: 32978483 Free PMC article. - Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence.
Vander Haar EL, So J, Gyamfi-Bannerman C, Han YW. Vander Haar EL, et al. Anaerobe. 2018 Apr;50:55-59. doi: 10.1016/j.anaerobe.2018.01.008. Epub 2018 Feb 2. Anaerobe. 2018. PMID: 29409815 Free PMC article. Review. - Association of pregnant women periodontal status to preterm and low-birth weight babies: A systematic and evidence-based review.
Shanthi V, Vanka A, Bhambal A, Saxena V, Saxena S, Kumar SS. Shanthi V, et al. Dent Res J (Isfahan). 2012 Jul;9(4):368-80. Dent Res J (Isfahan). 2012. PMID: 23162575 Free PMC article.
References
- Kinane DF, Bartold PM. Clinical relevance of the host responses of periodontitis. Periodontol 2000. 2007;43:278–293. - PubMed
- Tatakis DN, Kumar PS. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am. 2005;49:491–516. - PubMed
- Socransky SS, Haffajee AD. Periodontal microbial ecology. Periodontol 2000. 2005;38:135–187. - PubMed
- Nygren P, Fu R, Freeman M, Bougatsos C, Klebanoff M, Guise JM. Evidence on the benefits and harms of screening and treating pregnant women who are asymptomatic for bacterial vaginosis: An update review for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;148:220–233. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical