Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men - PubMed (original) (raw)

Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men

Devina Joshi et al. Clin Endocrinol (Oxf). 2010 Feb.

Abstract

Objective: The prevalence of both low testosterone levels and depression increases with age. Currently, there is no consensus regarding the existence of an association. Our study analyses the cross-sectional association of testosterone levels with depressive symptoms and its prospective association with the development of incident depressive symptoms.

Design: Longitudinal population-based study; based on the data of the Longitudinal Aging Study Amsterdam (LASA) including 608 men aged >or=65 years (median age 75.6 years).

Measurements: Linear and logistic regression between total and free testosterone levels and depressive symptoms as measured by the Center of Epidemiologic Studies Depression (CES-D) scale, taking into account medical and lifestyle factors. Cox Proportional Hazards model was used to assess incident depressive symptoms.

Results: Unadjusted linear regression between square-root transformed CES-D scores and free testosterone levels showed a significant inverse association as a continuous variable (beta = -0.10, P < 0.05), lowest quartile compared to highest (beta = 0.12, P < 0.05) and with a threshold value of 170 pmol/l (beta = 0.13, P < 0.05). The results remained significant for the group below threshold after adjustment for all confounders (beta = 0.09, P < 0.05). Cox Proportional Hazards Model showed a decreased risk for incident depressive symptoms for men with higher free testosterone levels [HR = 0.997 CI (0.995-1.000)]. Men with the threshold value below 220 pmol/l were at increased risk of incident depressive symptoms [HR = 1.989 CI (1.173-3.374)].

Conclusions: Free testosterone levels below 170 pmol/l are associated with depressive symptoms, while free testosterone levels below 220 pmol/l (lowest quintile of our population) predict the onset of depressive symptoms.

PubMed Disclaimer

Cited by

Associations of androgens with depressive symptoms and cognitive status in the general population.
Kische H, Gross S, Wallaschofski H, Grabe HJ, Völzke H, Nauck M, Haring R. Kische H, et al. PLoS One. 2017 May 12;12(5):e0177272. doi: 10.1371/journal.pone.0177272. eCollection 2017. PLoS One. 2017. PMID: 28498873 Free PMC article.
What has sex got to do with it? The role of hormones in the transgender brain.
Nguyen HB, Loughead J, Lipner E, Hantsoo L, Kornfield SL, Epperson CN. Nguyen HB, et al. Neuropsychopharmacology. 2019 Jan;44(1):22-37. doi: 10.1038/s41386-018-0140-7. Epub 2018 Jul 5. Neuropsychopharmacology. 2019. PMID: 30082887 Free PMC article. Review.
Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men.
Reynolds AC, Dorrian J, Liu PY, Van Dongen HP, Wittert GA, Harmer LJ, Banks S. Reynolds AC, et al. PLoS One. 2012;7(7):e41218. doi: 10.1371/journal.pone.0041218. Epub 2012 Jul 23. PLoS One. 2012. PMID: 22844441 Free PMC article. Clinical Trial.
Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood.
Reiss AB, Gulkarov S, Pinkhasov A, Sheehan KM, Srivastava A, De Leon J, Katz AE. Reiss AB, et al. Medicina (Kaunas). 2023 Dec 30;60(1):77. doi: 10.3390/medicina60010077. Medicina (Kaunas). 2023. PMID: 38256338 Free PMC article. Review.
Low DHEAS levels are associated with depressive symptoms in elderly Chinese men: results from a large study.
Wong SY, Leung JC, Kwok T, Ohlsson C, Vandenput L, Leung PC, Woo J. Wong SY, et al. Asian J Androl. 2011 Nov;13(6):898-902. doi: 10.1038/aja.2011.116. Epub 2011 Aug 29. Asian J Androl. 2011. PMID: 21874029 Free PMC article.

Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men - PubMed (original) (raw)