Clathrin-mediated endocytosis and Alzheimer's disease: an update - PubMed (original) (raw)
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Clathrin-mediated endocytosis and Alzheimer's disease: an update
Fangbai Wu et al. Ageing Res Rev. 2009 Jul.
Abstract
Thanks to new evidence we are now a step closer to understanding how neurons produce amyloid-beta peptide (Abeta)-the chief culprit of Alzheimer's disease. As importance of clathrin-mediated endocytosis to normal neurons has become clearer, so has its role in pathology of neurological disorders. Here we update recent evidence that endocytosis plays a central role in the production of Abeta in neurons.
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