Ghrelin regulates hippocampal neurogenesis in adult mice - PubMed (original) (raw)
Ghrelin regulates hippocampal neurogenesis in adult mice
Minho Moon et al. Endocr J. 2009.
Free article
Abstract
The aim of our study was to investigate the effect of the peripheral administration of ghrelin, a peptide hormone secreted from the stomach, on cellular proliferation and differentiation of progenitor cells in the adult hippocampus. Double immunohistochemical staining revealed that Ki-67-positive hippocampal progenitor cells expressed ghrelin receptors. In mice treated with ghrelin (80 microg/kg, i.p.) for 8 days, bromodeoxyuridine incorporation and doublecortin-positive neuroblasts were significantly increased in the dentate subgranular zone. We also found that the numbers of bromodeoxyuridine- and doublecortin-immunoreactive cells were significantly reduced after anti-ghrelin antibody (10 microg/kg, i.p.) treatment for 8 days. Therefore, our results indicate that ghrelin induces proliferation and differentiation of adult hippocampal progenitors, suggesting an involvement of ghrelin in hippocampal neurogenesis.
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