Parkinson's disease - PubMed (original) (raw)

Review

Parkinson's disease

Andrew J Lees et al. Lancet. 2009.

Erratum in

• Lancet. 2009 Aug 29;374(9691):684

Abstract

Parkinson's disease is a common progressive bradykinetic disorder that can be accurately diagnosed. It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation of aggregated alpha-synuclein in specific brain stem, spinal cord, and cortical regions. The main known risk factor is age. Susceptibility genes including alpha-synuclein, leucine rich repeat kinase 2 (LRRK-2), and glucocerebrosidase (GBA) have shown that genetic predisposition is another important causal factor. Dopamine replacement therapy considerably reduces motor handicap, and effective treatment of associated depression, pain, constipation, and nocturnal difficulties can improve quality of life. Embryonic stem cells and gene therapy are promising research therapeutic approaches.

PubMed Disclaimer

Similar articles

• Precision medicine in Parkinson's disease patients with LRRK2 and GBA risk variants - Let's get even more personal.
  von Linstow CU, Gan-Or Z, Brundin P. von Linstow CU, et al. Transl Neurodegener. 2020 Oct 16;9(1):39. doi: 10.1186/s40035-020-00218-x. Transl Neurodegener. 2020. PMID: 33066808 Free PMC article. Review.
• Resequencing analysis of five Mendelian genes and the top genes from genome-wide association studies in Parkinson's Disease.
  Benitez BA, Davis AA, Jin SC, Ibanez L, Ortega-Cubero S, Pastor P, Choi J, Cooper B, Perlmutter JS, Cruchaga C. Benitez BA, et al. Mol Neurodegener. 2016 Apr 19;11:29. doi: 10.1186/s13024-016-0097-0. Mol Neurodegener. 2016. PMID: 27094865 Free PMC article.
• Autosomal dominant Parkinson's disease and the route to new therapies.
  Morris HR. Morris HR. Expert Rev Neurother. 2007 Jun;7(6):649-56. doi: 10.1586/14737175.7.6.649. Expert Rev Neurother. 2007. PMID: 17563248 Review.
• [Pathogenesis of sporadic Parkinson's disease: contribution of genetic and environmental risk factors].
  Takahashi R, Kawamata J, Takeuchi H. Takahashi R, et al. Rinsho Shinkeigaku. 2009 Nov;49(11):885-7. doi: 10.5692/clinicalneurol.49.885. Rinsho Shinkeigaku. 2009. PMID: 20030238 Review. Japanese.
• Glucocerebrosidase activity in Parkinson's disease with and without GBA mutations.
  Alcalay RN, Levy OA, Waters CC, Fahn S, Ford B, Kuo SH, Mazzoni P, Pauciulo MW, Nichols WC, Gan-Or Z, Rouleau GA, Chung WK, Wolf P, Oliva P, Keutzer J, Marder K, Zhang X. Alcalay RN, et al. Brain. 2015 Sep;138(Pt 9):2648-58. doi: 10.1093/brain/awv179. Epub 2015 Jun 27. Brain. 2015. PMID: 26117366 Free PMC article.

Cited by

• Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
  Rocha EM, Smith GA, Park E, Cao H, Brown E, Hallett P, Isacson O. Rocha EM, et al. Ann Clin Transl Neurol. 2015 Apr;2(4):433-8. doi: 10.1002/acn3.177. Epub 2015 Feb 6. Ann Clin Transl Neurol. 2015. PMID: 25909088 Free PMC article.
• Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease.
  Lee BD, Dawson VL, Dawson TM. Lee BD, et al. Trends Pharmacol Sci. 2012 Jul;33(7):365-73. doi: 10.1016/j.tips.2012.04.001. Epub 2012 May 9. Trends Pharmacol Sci. 2012. PMID: 22578536 Free PMC article. Review.
• Othello syndrome in Parkinson's disease: a systematic review and report of a case series.
  De Michele G, Palmieri GR, Pane C, Dello Iacovo CDP, Perillo S, Saccà F, De Michele G, De Rosa A. De Michele G, et al. Neurol Sci. 2021 Jul;42(7):2721-2729. doi: 10.1007/s10072-021-05249-4. Epub 2021 May 12. Neurol Sci. 2021. PMID: 33978871 Free PMC article. Review.
• Patient-Derived Induced Pluripotent Stem Cell-Based Models in Parkinson's Disease for Drug Identification.
  Kouroupi G, Antoniou N, Prodromidou K, Taoufik E, Matsas R. Kouroupi G, et al. Int J Mol Sci. 2020 Sep 26;21(19):7113. doi: 10.3390/ijms21197113. Int J Mol Sci. 2020. PMID: 32993172 Free PMC article. Review.
• Neuroprotective Effects of Cryptotanshinone in a Direct Reprogramming Model of Parkinson's Disease.
  Lee JE, Sim H, Yoo HM, Lee M, Baek A, Jeon YJ, Seo KS, Son MY, Yoon JS, Kim J. Lee JE, et al. Molecules. 2020 Aug 7;25(16):3602. doi: 10.3390/molecules25163602. Molecules. 2020. PMID: 32784741 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal