Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. The Capsaicin Study Group - PubMed (original) (raw)
Clinical Trial
Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. The Capsaicin Study Group
No authors listed. Arch Intern Med. 1991 Nov.
Abstract
A multicenter study was conducted to establish the efficacy of topical 0.075% capsaicin cream in relieving the pain associated with diabetic neuropathy. Capsaicin or vehicle cream was applied to painful areas four times per day for 8 weeks in patients randomly assigned to one of two groups. Pain intensity and relief were recorded at 2-week intervals using physician's global evaluation and visual analog scales. Analysis at final visit for 252 patients showed statistical significance favoring capsaicin compared with vehicle for the following: 69.5% vs 53.4% pain improvement by the physician's global evaluation scale, 38.1% vs 27.4% decrease in pain intensity, and 58.4% vs 45.3% improvement in pain relief. With the exception of transient burning, sneezing, and coughing, capsaicin was well tolerated. Study results suggest that topical capsaicin cream is safe and effective in treating painful diabetic neuropathy.
Similar articles
- Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Capsaicin Study Group.
[No authors listed] [No authors listed] Diabetes Care. 1992 Feb;15(2):159-65. doi: 10.2337/diacare.15.2.159. Diabetes Care. 1992. PMID: 1547671 Clinical Trial. - A double-blind comparison of topical capsaicin and oral amitriptyline in painful diabetic neuropathy.
Biesbroeck R, Bril V, Hollander P, Kabadi U, Schwartz S, Singh SP, Ward WK, Bernstein JE. Biesbroeck R, et al. Adv Ther. 1995 Mar-Apr;12(2):111-20. Adv Ther. 1995. PMID: 10150323 Clinical Trial. - Treatment of painful diabetic neuropathy with capsaicin 0.075%.
Scheffler NM, Sheitel PL, Lipton MN. Scheffler NM, et al. J Am Podiatr Med Assoc. 1991 Jun;81(6):288-93. doi: 10.7547/87507315-81-6-288. J Am Podiatr Med Assoc. 1991. PMID: 1920093 Clinical Trial. - Painful diabetic peripheral neuropathy of the feet: integrating prescription-strength capsaicin into office procedures.
Landrum O, Marcondes L, Egharevba T, Gritsenko K. Landrum O, et al. Pain Manag. 2023 Oct;13(10):613-626. doi: 10.2217/pmt-2023-0028. Epub 2023 Sep 26. Pain Manag. 2023. PMID: 37750226 Review.
Cited by
- Diabetic neuropathy and oxidative stress: therapeutic perspectives.
Hosseini A, Abdollahi M. Hosseini A, et al. Oxid Med Cell Longev. 2013;2013:168039. doi: 10.1155/2013/168039. Epub 2013 Apr 24. Oxid Med Cell Longev. 2013. PMID: 23738033 Free PMC article. Review. - Long-Term Oral Administration of Capsicum baccatum Extracts Does Not Alter Behavioral, Hematological, and Metabolic Parameters in CF1 Mice.
Zimmer AR, Leonardi B, Zimmer ER, Kalinine E, de Souza DO, Portela LV, Gosmann G. Zimmer AR, et al. Evid Based Complement Alternat Med. 2012;2012:196358. doi: 10.1155/2012/196358. Epub 2012 Dec 17. Evid Based Complement Alternat Med. 2012. PMID: 23320023 Free PMC article. - Treatment of chronic facial pain.
Lincoff NS. Lincoff NS. Curr Treat Options Neurol. 2006 Jan;8(1):69-79. doi: 10.1007/s11940-996-0025-7. Curr Treat Options Neurol. 2006. PMID: 16343362 - Pharmacological management of neuropathic pain.
McCleane G. McCleane G. CNS Drugs. 2003;17(14):1031-43. doi: 10.2165/00023210-200317140-00003. CNS Drugs. 2003. PMID: 14594443 Review. - Toxicokinetic Study of a Gastroprotective Dose of Capsaicin by HPLC-FLD Method.
Kuzma M, Fodor K, Almási A, Mózsik G, Past T, Perjési P. Kuzma M, et al. Molecules. 2019 Aug 5;24(15):2848. doi: 10.3390/molecules24152848. Molecules. 2019. PMID: 31387338 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical