Micromanipulating cancer: microRNA-based therapeutics? - PubMed (original) (raw)
Review
. 2009 Jul-Aug;6(3):335-40.
doi: 10.4161/rna.6.3.9013. Epub 2009 Jul 14.
Affiliations
- PMID: 19535911
- DOI: 10.4161/rna.6.3.9013
Review
Micromanipulating cancer: microRNA-based therapeutics?
Fabio Petrocca et al. RNA Biol. 2009 Jul-Aug.
Abstract
Because microRNAs regulate cancer cell differentiation, proliferation, survival and metastasis, manipulating microRNA function, either by mimicking or inhibiting miRNAs implicated in cancer, could provide a powerful therapeutic strategy to interfere with key pathways for cancer progression. This review will explore some of the opportunities and obstacles to harnessing microRNA biology for cancer therapy.
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