Foxp3+ regulatory T cells: differentiation, specification, subphenotypes - PubMed (original) (raw)

Review

doi: 10.1038/ni.1760.

Affiliations

• PMID: 19536194
• DOI: 10.1038/ni.1760

Review

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

Markus Feuerer et al. Nat Immunol. 2009 Jul.

Abstract

Regulatory T cells (T(reg) cells) characterized by expression of the transcription factor Foxp3 play a key role in immune homeostasis. Rather than a monomorphic population strictly determined by Foxp3 as a 'master regulator', the emerging view is one of T(reg) cells as a population with many levels of complexity. Several regulatory factors partake in the control of their transcriptional 'signature', with Foxp3 being a key regulator but insufficient and unnecessary to specify all aspects of the lineage. Distinct subphenotypes of Foxp3+ T(reg) cells are found in different anatomical locations. Some subphenotypes specifically control different facets of effector T cell function and, perhaps surprisingly, share transcriptional control elements with the very cells they regulate. This review will focus on these novel aspects of T(reg) cell diversity.

PubMed Disclaimer

Similar articles

• Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.
  Williams LM, Rudensky AY. Williams LM, et al. Nat Immunol. 2007 Mar;8(3):277-84. doi: 10.1038/ni1437. Epub 2007 Jan 14. Nat Immunol. 2007. PMID: 17220892
• Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.
  Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO. Ouyang W, et al. Nat Immunol. 2010 Jul;11(7):618-27. doi: 10.1038/ni.1884. Epub 2010 May 13. Nat Immunol. 2010. PMID: 20467422
• The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.
  Haxhinasto S, Mathis D, Benoist C. Haxhinasto S, et al. J Exp Med. 2008 Mar 17;205(3):565-74. doi: 10.1084/jem.20071477. Epub 2008 Feb 18. J Exp Med. 2008. PMID: 18283119 Free PMC article.
• Rethinking the molecular definition of regulatory T cells.
  Hori S. Hori S. Eur J Immunol. 2008 Apr;38(4):928-30. doi: 10.1002/eji.200838147. Eur J Immunol. 2008. PMID: 18395863 Review.
• FOXP3+ regulatory T cells in the human immune system.
  Sakaguchi S, Miyara M, Costantino CM, Hafler DA. Sakaguchi S, et al. Nat Rev Immunol. 2010 Jul;10(7):490-500. doi: 10.1038/nri2785. Epub 2010 Jun 18. Nat Rev Immunol. 2010. PMID: 20559327 Review.

Cited by

• Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes.
  Li CR, Baaten BJ, Bradley LM. Li CR, et al. J Mol Cell Biol. 2012 Feb;4(1):38-47. doi: 10.1093/jmcb/mjr040. Epub 2011 Nov 24. J Mol Cell Biol. 2012. PMID: 22116888 Free PMC article. Review.
• Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
  Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. Lowe MM, et al. JCI Insight. 2019 Dec 19;4(24):e129756. doi: 10.1172/jci.insight.129756. JCI Insight. 2019. PMID: 31852848 Free PMC article.
• FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development.
  Haque R, Lei F, Xiong X, Wu Y, Song J. Haque R, et al. Arthritis Res Ther. 2010;12(2):R66. doi: 10.1186/ar2983. Epub 2010 Apr 12. Arthritis Res Ther. 2010. PMID: 20384988 Free PMC article.
• Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog.
  Pinheiro D, Singh Y, Grant CR, Appleton RC, Sacchini F, Walker KR, Chadbourne AH, Palmer CA, Armitage-Chan E, Thompson I, Williamson L, Cunningham F, Garden OA. Pinheiro D, et al. Immunology. 2011 Jan;132(1):111-22. doi: 10.1111/j.1365-2567.2010.03346.x. Epub 2010 Sep 30. Immunology. 2011. PMID: 20880379 Free PMC article.
• Distribution of Th17 cells and FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer.
  Maruyama T, Kono K, Mizukami Y, Kawaguchi Y, Mimura K, Watanabe M, Izawa S, Fujii H. Maruyama T, et al. Cancer Sci. 2010 Sep;101(9):1947-54. doi: 10.1111/j.1349-7006.2010.01624.x. Cancer Sci. 2010. PMID: 20550524 Free PMC article.

References

1. 1. J Immunol. 2005 Jul 1;175(1):246-53 - PubMed
2. 1. Nat Immunol. 2007 Sep;8(9):967-74 - PubMed
3. 1. J Immunol. 2007 Apr 1;178(7):4022-6 - PubMed
4. 1. Immunity. 2006 Sep;25(3):455-71 - PubMed
5. 1. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4566-71 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database